CYSTEINE PROTEINASE ACTIVITY IN CHILDREN WITH HEMANGIOMA

Cover Page


Cite item

Full Text

Abstract

Objective - study of activity of cysteine proteases - cathepsins B, L, H, and their endogenous inhibitor cystatin C, vascular endothelial growth factor in tumor tissue, skin and blood serum of children with hemangiomas. Material was obtained from 39 patients (42 hemangiomas) and 24 healthy children. It was found that the level of the studied parameters in serum and skin of healthy children regardless of the age of the child. Their activity in blood serum, skin, tumor tissue of patients with hemangiomas significantly higher than that in serum of healthy skin and children. A very large coefficient of variation for all parameters in all the studied biological substrates is not possible to use them as diagnostic markers.

About the authors

N. A. Dementieva

ME «Regional Children Hospital of Dnipropetrovsk»

Author for correspondence.
Email: dementievana@ukr.net
Россия

O. U. Borenko

ME «Regional Children Hospital of Dnipropetrovsk»

Email: borenko.olga@mail.ru
Россия

O. L. Lyanna

SE «Dnipropetrovsk Medical Academy» of the Ministry of Health of Ukraine

Email: olga_313@mail.ru
Россия

References

  1. Вовчук И.Л. Прогностическое значение определения катепсина и его эндогенных ингибиторов при опухолевой патологии // Онкология. 2010. № 2. С. 165-168.
  2. Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ Statistica. - М.: Медиа Сфера, 2002. - 312 с.
  3. Суринов Б.Г., Манойлов С.Е. Определение активности протеолитических ферментов с помощью азоказеина // Вопросы мед. химии. 1965. Т. 11, № 5. С. 55-58.
  4. Черная В.И., Рева А.Д. Активность катепсина Н в мозге и опухолях мозга человека // Укр. биохим. журн. 1989. Т. 61, № 5. С. 47-50.
  5. Чорна В.I., Лянна О.Л. Лiзосомнi цистеiновi протеази: молекулярна структура i функцп: Монографiя. - Харюв: Екограф, 2013. - 296 с.
  6. Barrett A., Kirschke H. Cathepsin B, cathepsin H, and cathepsin L // Methods Enzymol. 1981. Vol. 80. P. 535-561.
  7. Boye E., Olsen B.R. Signaling mechanisms in infantile hemangioma // Curr. Opin. Hematol. 2009. Vol. 16, № 3. Р. 202-208.
  8. Chang L.C., Haggstrom A.N., Drolet Beth A. et al. Growth characteristics of infantile hemangiomas: implications for management // Pediatrics. 2010. Vol. 126, № 6. Р. 1589-1593.
  9. Chen T.S., Eichenfield L.F., Friedlander Sh. F. Infantile hemangiomas: an update on pathogenesis and therapy // Pediatrics. 2013. Vol. 131, № 2. Р 99-108.
  10. Cremer H. Hamangiome: klassifizierung und therapieempfehlungen // Padiatrie hautnah. - 2009. - Bd. 21, № 2. - S. 133-146.
  11. Enjolras O., Wassef M., Chapot R. Color Atlas of Vascular Tumors and Vascular Malformations. - Cambridge University Press, 2007. - 310 p.
  12. Gocheva V., Chen X., Peters Chr., Reinheckel Th., Joyce J.A. Deletion of cathepsin H perturbs angiogenic switching, vascularization and growth of tumors in a mouse model of pancreatic islet cell cancer // Biol. Chem. 2010. Vol. 391, № 8. P. 937-945.
  13. Mulliken J.B., Young A.E. Vascular birthmarks. Hemangiomas and malformations. - W.B. Sounders and Co., 1988. P. 39-65.
  14. Przewratil P., Sitkiewicz A., Andrzejewska E. Local serum levels of vascular endothelial growth factor in infantile hemangioma: intriguing mechanism of endothelial growth // Cytokine. 2010. Vo. 49, № 2. P. 141-147.
  15. Rajewska J., Gawrych E., Fischer K., Walecka A., Brzosko M., Kwas A. Estimation of vascular endothelial growth factor and placental growth factor serum levels’ in infant with hemangioma and population of healthy infants // Ann. Acad.Med. Stetin. 2012. Vol. 58, № 2. P. 5-10.
  16. Schwartz W.N., Barrett A.J. Human cathepsin H // Biochem. J. 1980. Vol. 191, № 2. P. 487-497.
  17. Veillard Fl., Saidi Ahl., Burden R.E., Scott Chr.J., Gillet L., Lecaille F., Lalmanach G. Cysteine Cathepsins S and L Modulate Antiangiogenic Activities of Human Endostatin // J. Biol. Chem. 2011. Vol. 286. P 37 158-37 167.
  18. Zhong S., Yang G., Xia C., Duanlian Z., Shan S. Expression of matrix metalloproteinase and its tissue inhibitor in haemangioma // J. Huazhong Univ. Sci. Technolog. Med. Sci. 2009. Vol. 29. P. 614-619.
  19. Zimmermann A.P., Wiegand S., Werner J.A., Eivazi B. Propranolol therapy for infantile haemangiomas: Review of the literature // Int.J. Pediatr. Otorhinolaryngology. 2010. Vol. 74. P. 338-342.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2014 Dementieva N.A., Borenko O.U., Lyanna O.L.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ПИ № ФС 77 - 81892 от 24.09.2021 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies