Extracorporeal hemocorrection in treatment of meningococcal septic shock in children

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Purpose: to estimate the effectiveness of extracorporeal hemocorrection in treatment of refractory meningococcal septic shock in children.

Methods: patients with generalized form of meningococcal infection, multi-organ system failure and refractory septic shock admitted to the resuscitation department of Children’s Clinical Research Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia underwent extracorporeal hemocorrection (polymyxin adsorption, continuous veno-venous hemofiltration, continuous veno-venous hemodiafiltration). MultiFiltrate apparatus was used (Fresenius Medical Care, Germany).

Results: application of extracorporeal hemocorrection technique in the therapy of refractory meningococcal septic shock reduced the mortality from 44.4% to 25%.

Conclusion: effectiveness of extracorporeal hemocorrection when treating patients with refractory meningococcal septic shock is established. A small number of examined patients is a limitation of the study.

作者简介

Konstantin Serednyakov

Children’s Clinical Research Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia

编辑信件的主要联系方式.
Email: spbny@yahoo.com

Head of ICU; Assistant of the Department of anesthesiology – resuscitation and emergency pediatrics of St. Petersburg pediatric medical University

Prof. Popov st. 9, St. Petersburg, Russia, 197022; phone: +7(911)134–11–21

俄罗斯联邦

Yuri Lobzin

Children’s Clinical Research Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia

Email: niidi@niidi.ru

Dr. Sci (Med), Professor, Director of “Children’s Clinical Research Center for Infectious Diseases of the Federal Medical and Biological Agency of Russia”; head of the Department of infectious diseases “North-Western state medical University named after I. I. Mechnikov”, honored scientist of the Russian Federation, General of medical service, academician of RAS

Prof. Popov st. 9, St. Petersburg, Russia, 197022

俄罗斯联邦

参考

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  5. Kohro S., Imaizumi H., Yamakage M., Masuda Y., Namiki A., Asai Y., Maruyama I. Anandamide absorption by direct hemoperfusion with polymixin B-immobilized fiber improves the prognosis and organ failure assessment score in patients with sepsis. J. Anesth. 2006;(20):11-6. PMID: 16421670. doi: 10.1007/s00540-005-0366-5.
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