RISK FACTORS OF CHRONIC RENAL DISEASE PROGRESSION IN CHILDREN WITH CONGENITAL DEFECTS OF THE URINARY TRACT IN THE POSTOPERATIVE PERIOD

The purpose of the study was to find independent and attributive predictors of progression of chronic renal disease (CRD) in children who underwent a surgery for congenital defects of the urinary tracts.

Methods. It was a retrospective, observational and cohort study. The inclusion criteria were congenital abnormality of the kidneys and urinary tracts, glomerular filtration rate (GFR) <90 ml/min/1.73 m2, patients less than 18 years old. 297 patients were included in the study. The data were statistically processed using «Statistica 6.0» and MedCalc (MedCalcSoftware, Belgium).

Results. We found out that the glomerular filtration rate at the stage of primary hospitalization (RR = 9.40) and arterial hypertension (OR = 4.40) were the only independent predictors of the CRD progression. The combination of the two types were shown using the area under ROC-curve (0.756) which was significantly (р<0.005) higher than the isolated value of the symptoms.

Conclusions. The attributive risk factor of CRD progression in children who had a surgery for congenital defects of the urinary tracts is arterial hypertension (AH). The independent risk factor are GFR and AH. Their combination significantly increases the risk (р<0.005) of chronic renal disease progression.