STRUCTURAL CHANGES IN THE INTESTINAL WALL IN IMPLEMENTATION OF THE SYNDROME OF INTESTINAL DYSMOTILITY IN CHILDREN WITH GASTROSCHISIS
- 作者: Babuch S.1, Tika K.2, Petrovich V.3, Sinitsina L.3, Zhalbe A.1, Negru I.1
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隶属关系:
- Nikolai Testemitsanu State University of Medicine & Pharmacy
- Ovidius University, Constanta
- Public Health Establishment the Institute of Mother and Child
- 期: 卷 6, 编号 4 (2016)
- 页面: 13-19
- 栏目: Original Study Articles
- ##submission.dateSubmitted##: 10.06.2017
- ##submission.dateAccepted##: 10.06.2017
- ##submission.datePublished##: 10.12.2016
- URL: https://rps-journal.ru/jour/article/view/286
- DOI: https://doi.org/10.17816/psaic286
- ID: 286
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The authors presented the results of histopathological and immunohistochemical studies using autopsy material (22 newborns who died of gastroschisis). According to the results, in all the cases inflammation of the parietal and visceral peritoneum were of productive, proliferative and fibroplastic origin. In the majority of cases, an acute purulent inflammation with formation of abscesses at the level of the eviscerated intestinal loops was revealed.
In some cases the acute inflammation process was manifested through leukocytic erosive and abscessed inflammatory exudative fibrinous lesions at the level of the parietal and visceral peritoneum involving the entire intestinal wall in the process. The presence of only one mainly circular muscular layer was a peculiar feature found in the eviscerated intestinal loops with the external muscular layer undergoing regional hypoplasia or aplasia.
Results of the conducted study helped the authors to determine the combination of neuromuscular structural changes of the eviscerated intestinal loops and find the relation of the implementation of the intestinal motility stable disturbances in newborns with gastroschisis.
作者简介
S. Babuch
Nikolai Testemitsanu State University of Medicine & Pharmacy
编辑信件的主要联系方式.
Email: babuci@newmail.ru
Доктор медицинских наук, доцент, ведущий научный сотрудник лаборатории «Хирургическая инфекция у детей» кафедры детской хирургии, ортопедии и анестезиологии 摩尔多瓦共和国
K. Tika
Ovidius University, Constanta
Email: tica.constantin@yahoo.com
медицинских наук, профессор, заведующий кафедрой детской хирургии 罗马尼亚
V. Petrovich
Public Health Establishment the Institute of Mother and Child
Email: petrovicivergil@yahoo.com
Кандидат медицинских наук, старший научный сотрудник, заведующий отделением патологической анатомии 摩尔多瓦共和国
L. Sinitsina
Public Health Establishment the Institute of Mother and Child
Email: lily10feb@rambler.ru
Кандидат медицинских наук, доцент, зав. научного отдела морфопатологии 摩尔多瓦共和国
A. Zhalbe
Nikolai Testemitsanu State University of Medicine & Pharmacy
Email: sandujalba@gmail.com
Кандидат медицинских наук, доцент, кафедра детской хирургии, ортопедии и анестезиологии 摩尔多瓦共和国
I. Negru
Nikolai Testemitsanu State University of Medicine & Pharmacy
Email: ionnegru@yahoo.com
Заведующий отделением гнойной хирургии, аспирант кафедры детской хирургии, ортопедии и анестезиологии 摩尔多瓦共和国
参考
- Islam S. Clinical care outcomes in abdominal wall defects. Curr. Opin. Pediatr. 2008. 20 (3):305–10.
- de Buys Roessingh A. S., Damphousse A., Ballabeni P. et al. Predictive factors at birth of the severity of gastroschisis. World J. Gastrointest. Pathophysiol. 2015. 6 (4):228–34.
- Henrich K., Huemmer H. P., Reingruber B., Weber P. G. Gastroschisis and omphalocele: treatments and long-term outcomes. Pediatr. Surg. Int. 2008. 24:167–73.
- Correia-Pinto J., Tavares M. L., Baptista M. J. et al. A new fetal rat model of gastroschisis: development and early characterization. J. Pediatr. Surg. 2001. 36:213–6.
- Lao O. B., Larison C., Garrison M. M. et al. Outcomes in neonates with gastroschisis in U. S. children‘s hospitals. Am. J. Perinatol. 2010. 27:97–101.
- Page R., Ferraro Z. M., Moretti F., Fung K. F. Gastroschisis: antenatal sonographic predictors of adverse neonatal outcome. J. Pregnancy. 2014:239406. doi: 10.1155/2014/239406.
- Auber F., Danzer E., Noche-Monnery M. E. et al. Enteric nervosus system impairment in gastroschisis. Eur. J. Pediatr. Surg. 2013. 12:29–38.
- Correia-Pinto J., Tavares M. L., Baptista M. J. et al. Meconium dependence of bowel damage in gastroschisis. J. Pediatr. Surg. 2002. 37 (1):31–5.
- Franca W. M., Langone F., de la Hoz C. L. et al. Maturity of the myenteric plexus is descreased in the gastroschisis rat model. Fetal Diagn. Ther. 2008. 23 (1):60–8.
- Taguchi T., Masumoto K., Ieiri S. et al. New classification of jypoganglionosis: congenital and acquired hypoganglionosis. J. Pediatr. Surg. 2006. 41:2046–51.
- Le Quesne G. W., Reilly B. J. Functional immaturity of the large bowel in the newborn infant. Radiol Clin North Am 1975;13:331–42.
- Khen N., Jaubert F., Sauvat F. et al. Fetal intestinal obstruction induces alteration of enteric nervous system development in human intestinal atresia. Pediatr. Res. 2004. 56:975–80.
- Feldkamp M. L., Carey J. C., Sadler T. W. Development of gastroschisis: review of hypotheses, a novel hypothesis, and implications for research. Am. J. Med. Genet. A. 2007. 143:639–52.
- Ionescu S., Mocanu M., Andrei B. et al. Differential diagnosis of abdominal wall defects – omphalocele versus gastroschisis. Chirurgia. 2014. 109:7–14.
- Roelofs L. A. J., Geutjes P. J., Hulsbergen-van de Kaa C. A. et al. Prenatal coverage of experimental gastroschisis with a collagen scaffold to protect the bowel. J. Pediatr. Surg. 2013. 48:516–24.
- Shah S. K., Aroom K. R., Walker P. A. et al. Effects of nonoclusive mesenteric hypertension on intestinal function: implications for gastroschisis-related intestinal dysfunction. Pediatr. Res. 2012. 71 (6):668–74.
- Moore-Olufemi S. D., Olsen A. B., Hook-Dufresne et al. Transforming growth factor-beta 3 alters intestinal smooth muscle function: implications for gastroschisis-related intestinal dysfunction. Dig. Dis. Sci. 2015. 60:1206–14.
- Midrio P., Vannycchi M. G., Pieri L. et al. Delayed development of interstitial cells of Cajal in the ileum of a human case of gastroschisis. J. Cell. Mol. Med. 2008. 12 (2):471–8.
- Zani-Ruttenstock E., Zani A., Paul A. et al. Interstitial cells of Cajal are decreased in patients with gastroschisis associated intestinal dysmotility. J. Pediatr. Surg. 2015. 50:750–4.