Email this article 
INFANTILE SOFT TISSUE FIBROSARCOMA OF THE FEMUR IN A 3-MONTH OLD CHILD
- Authors: Sharoev T.A.1, Sukharev A.V.1, Ivanova N.M.1, Klimchuk O.V.1, Roschin V.Y.2
-
Affiliations:
- Scientific and Practical Center for Medical Aid to Children of the Moscow Department of Health
- Federal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology of the Ministry of Health of the Russian Federation
- Issue: Vol 4, No 2 (2014)
- Pages: 81-86
- Section: Case reports
- URL: https://rps-journal.ru/jour/article/view/44
- DOI: https://doi.org/10.17816/psaic44
- ID: 44
Cite item
Full Text
Abstract
Infantile fibrosarcoma (IF) is a rare soft tissue tumor in the pediatric age group. Domestic and foreign literature usually provides single case reports of oncopathology in newborns and infants. A 2-month-old child was examined in a department of surgical oncology of the Scientific and Practical Center for Medical Aid to Children of the Moscow Department of Health who was admitted to the clinic in the end of December of 2013 for examination and treatment for a soft tissue tumor of the right femur. Fibrous soft tissue hamartoma was diagnosed based on the results from medical imaging studies (ultrasound examination, CT angiography) and verification by histology (tumor biopsy). The soft tissue tumor was removed. Histological and immunohistological analysis oftumor tissue confirmed the diagnosis of infantile fibrosarcoma. Radicality of the performed surgical intervention was confirmed microscopically. The child underwent multiagent chemotherapy in the postoperative period. Literature data regarding tumor frequency are provided stating an opinion of oncologists in treatment methods of this rare tumor in newborns and infants.
About the authors
T. A. Sharoev
Scientific and Practical Center for Medical Aid to Children of the Moscow Department of Health
Author for correspondence.
Email: timuronco@mail.ru
Russian Federation
A. V. Sukharev
Scientific and Practical Center for Medical Aid to Children of the Moscow Department of Health
Email: noemail@neicon.ru
Russian Federation
N. M. Ivanova
Scientific and Practical Center for Medical Aid to Children of the Moscow Department of Health
Email: noemail@neicon.ru
Russian Federation
O. V. Klimchuk
Scientific and Practical Center for Medical Aid to Children of the Moscow Department of Health
Email: noemail@neicon.ru
Russian Federation
V. Y. Roschin
Federal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology of the Ministry of Health of the Russian Federation
Email: noemail@neicon.ru
Russian Federation
References
- Akyuz C., Sari N., Gedikoglu G., Haliloglu M., Buyukpamukcu M. Newborn with infantie fibrosarcoma of foot: treatment with chemotherapy and extremity-sparing surgery // J. Perinatol. 2010. Vol. 1, N 30. P. 63-65.
- Al-Salem A.H. Congenitale-infantile fibrosarcoma masquerading as sacrococcygeal teratoma // J. Pediatr. Serg. 2011. Vol. 11, N 46. P. 2177-2180.
- Albert A., Cruz O., Montaner A., Vela A., Badosa J., Castarion M., Morales L. Congenital solid tumors. A thirteen-year review // Cir. Pediatr. 2004. Vol. 3, N 17. P. 133-136.
- Duan S., Zhang X., Wang G., Zhong J., Yang Z., Jiang X., Li J. Primary giant congenital fibrosarcoma on the left forearm // Chir. Main. 2013. Vol. 4, N 32. P. 265-267.
- Jain D., Kohli K. Congenitale infantile fibrosarcoma: a clinical mimicker of hemangioma // Cutis. 2012. Vol. 2, N 89. P. 61-64.
- Hu Z., Chou P.M., Jennings L.J., Arva N.C. Infantile fibrosarcoma - a clinical and histologic mimicker of vascular malformations: case report and review of the literature // Pediatr. Dev. Pathol. 2013. Vol. 5, N 16. P. 357-363.
- Loh M.L., Ahn P., Perez-Atayde A.R., Gebhardt M.C., Shamberger R.C., Grier H.E. Treament of infantile fibrosarcoma with chemotherapy and surgery: results from Dana-Farber Cancer Institute and Childrens Hospital, Boston // J. Pediatr. Hematol. Oncol. 2002. Vol. 9, N 24. P. 722-726.
- Mrad K., Dubus P., Bougrine F., Ben Salah H., Sassi S., Rammeh S., Driss M. et al. Infantile fibrosarcoma: a clinicopathological and molecular study of five cases // Ann. Pathol. 2001. Vol. 5, N 21. P. 387-392.
- Orbach D., Rey A., Ceccheto G., Oberlin O., Casanova M. et al. Infantile fibrosarcoma: management based on European exrerience // J. Clin. Oncol. 2010. Vol. 6, N 28. P. 318-323.
- Panda L., Fernandez-Pineda I., Uffman J.K., Davidoff A.M., Krasin M.J., Pappo A., Rao B.N. Clinical management of infantile fibrosarcoma: a retrospective single-institution review // Pediatr. Surg. Int. 2013. Vol. 7, N 29. P. 703-708.
- Parida L., Fernandez-Pineda I., Uffman J.K., Davidoff A.M., Krasin M.J., Pappo A., Rao B.N. Clinical management of infantile fibrosarcoma: a retrospective single-institution review // Pediatr. Surg. Int. 2013. Vol. 7, N 29. P. 703-708.
- Sulkowski J.P., Raval M.V., Browne M. Margin status and multimodal therapy in infantile fibrosarcoma // Pediatr. Surg. Int. 2013. Vol. 8, N 29. P. 771-776.
- Sultan I., Casanova M., Al-Jumaily U., Meazza C., Rodriguez-Galindo C., Ferrari A. Soft tissue sarcomas in the first year of life // Eur.J. Cancer. 2010. Vol. 13, N 46. P. 2449-2456.
- Russel H., Hicks M.J., Bertuch A.A., Chintagumpala M. Infantile fibrosarcoma: a clinical and histologic responses to cytotoxic chemotherapy // Pediatr. Blood Cancer. 2009. Vol. 1, N 53. P. 23-27.
Supplementary files
