Cover Page

Cite item


Benign liver tumors in children include neoplasms, unique only to childhood, as well as tumors that are more specific for adults. Although primary tumors of the liver constitute a small percentage of solid tumors in children, they are quite common in practice, pediatric surgeon and radiologist. The most common benign non-cystic liver in children education in descending order - infantile hemangioendothelioma, FNG, mesenchymal hamartoma, nodular regenerative hyperplasia and hepatocellular adenoma. Currently there is no single view of terminology, classification, diagnosis and treatment of benign hypervascular liver formations. The paper presents our views on this issue, the proposed algorithms for diagnosis and treatment.

About the authors

Y. A. Polyaev

Russian Children's Clinical Hospital of the Russian Federation

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

A. G. Narbutov

Russian Children's Clinical Hospital of the Russian Federation

Email: anarbutov@mail.ru
Russian Federation

A. A. Myl'nikov

Russian Children's Clinical Hospital of the Russian Federation

Email: noemail@neicon.ru
Russian Federation

R. V. Garbuzov

Russian Children's Clinical Hospital of the Russian Federation

Email: noemail@neicon.ru
Russian Federation


  1. Ochsner J.L., Halpert В.В. Cavernous hemangioma of the liver// Surgery. 1958. Vol. 43, N 4. P. 577-582.
  2. Mulliken J.B., Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics //Plast. Reconstr. Surg. 1982. Vol. 69, N 3. P. 412-422.
  3. Mo.I.Q., Dimashkieh H.H., Bove K.E. GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular mal-fonnation with associated capillary proliferation // Hum. Pathol. 2004. Vol. 35, N 2. P. 200-209.
  4. Hernandez F., Navarro М., Encinas J.L. et al. The role of GLUT1 immunostaining in the diagnosis and classification of liver vascular tumors in children // J. Pediatr. Surg. 2005. Vol. 40, N 5. P. 801-804.
  5. Enjolras O., Wassef M. Chapot R. etal. Coloratlas of vascular trnnors and vascular malfonnations. - Cambridge, 2007.-P. 3-11.
  6. Pratt G.A. Birthmarks in infants // Arch. Dennatol. 1953. Vol. 67. P. 302-305.
  7. Holmdahl K. Cutaneous hemangiomas in premature and mature infants // Acta Paediatr. 1955. Vol. 44. P. 370-379.
  8. Ishak K.G., Goodman Z.D., Stocker J.T. Benign mesenchymal tumors and pseudotumors // J. Rosai, L. Sobin (eds.). Atlas of tumor pathology: tumors of the liver and intrahepatic bile ducts. - Washington. DC: Armed Forces Institute of Pathology, 2001. P. 71-157.
  9. Boon L.M., Burrows P.E., Paltiel H.J. et al. Hepatic vascular anomalies in infancy: a twenty-seven-year experience // J. Pediatr. 1996. Vol. 129, N 3. P. 346-354.
  10. Ishak K.G., Anthonlv P.P., Niederau C., Nakanuma Y. Mesenchymal tumours of the liver// S.R. Hamilton, L. A. Aatonen (eds.). World Health Organization classification of tumours: tumours of the digestive system. - Lyon, France: IARC Press, 2000. P. 191-198.
  11. Данильченко С.А. Морфология гемангиом, гемангиоперицитом и гемангиоэндотелиом: Дис.. канд. мед. наук. - Донецк, 1974.
  12. Гранов А.М., Полысалов В.Н. Гемангиомы печени: Монография. - СПб.: Гиппократ, 1999.
  13. Ishak K.G., Goodman Z.D., Stocker J.T. Benign hepatocellular tumors // J. Rosai, L. Sobin (eds.). Atlas of tumor pathology: tumors of the liver and intrahepatic bileducts. - Washington, DC: Armed Forces Institute of Pathology, 2001. Р. 9-48.
  14. Stocker J.T. Hepatic tumors in children // Clin. Liver Dis. 2001. Vol. 5, N 1. Р. 259-281.
  15. Meyers R.L. Tumors of the liver in children // Surg. Oncol. 2007. Vol. 16, N 3. Р. 195-203.
  16. Stocker J.T., Ishak K.G. Mesenchymal hamartoma of the liver: report of 30 cases and review of the literature // Pediatr. Pathol. 1983. Vol. 1, N 3. Р 245-267.
  17. Siegel M.J., Chung E.M., Conran R.M. Pediatric liver: focal masses // Magn. Reson. Imaging. Clin.N. Am. 2008. Vol. 16, N 3. Р 437-452.
  18. Resnick M.B., Kozakewich H.P, Perez-Atayde A.R. Hepatic adenoma in the pediatric age group: clini- copathological observations and assessment of cell proliferative activity // Am.J. Surg. Pathol. 1995. Vol. 19, N 10. Р. 1181-1190.
  19. Brancatelli G., Federle M.P., Vullierme M.P., Lagalla R., Midiri M., Vilgrain V. CT and MR imaging evaluation of hepatic adenoma // J. Comput. Assist. Tomogr. 2006. Vol. 30, N 5. Р. 745-750.
  20. Grazioli L., Federle M.P., Brancatelli G., Ichikawa T., Olivetti L., Blachar A. Hepatic adenomas: imaging and pathologic findings // RadioGraphics. 2001. Vol. 21, N 4. Р. 877-892; discussion Р 892-894.
  21. Васильев Л.И. О гемангиомах печени // Клин. мед. 1963. № 1. С. 140-142.
  22. Conter R.L., Longmier Jr.W.P. Recurrent hepatic hemangiomas. Possible association with estrogen treatment // Ann. Surg. 1988. Vol. 207, N 2. Р 115-119.
  23. Sherlock S. Discases of the liver and biliary system. - Oxford: Blackwell, 1975. - 821 р.
  24. Лидский А.Т. Хирургические заболевания печени и желчевыводящей системы. - М., 1963. С. 178-187.
  25. Петровский Б.В. Хирургическая гепатология. - М., 1972.
  26. Меламуд М.Я., Фишбейн А.В. Гемангиомы печени // Клин. мед. 1983. № 8. С. 16-19.
  27. Erbay A. et al. Propranolol for infantile haemangiomas: a preliminary report on efficacy and safety in very low birth weight infants // Turk. J. Pediatr. 2010, Sep-Oct. Vol. 52, N 5. Р. 450-456.
  28. Storch C.H., Hoeger P.H. Propranolol for infantile haemangiomas: insigts into the molecular mechanisms of action // Br. J. Dermatol. 2010, Aug. Vol. 163, N 2. Р 269-274.
  29. Поляев Ю.А., Постников С.С., Мыльников А.А., Нарбутов А.Г. Место пропранолола в лечении инфантильных гемангиом // Детская больница. 2012. № 4.
  30. Левицкий Э.О., Кравченко Р.А. Спонтанный разрыв печени с множественными кавернозными гемангиомами // Клин. хир. 1971. № 3. С. 55-56.
  31. Прокопенко В.Я., Гнатюк М.С. К диагностике гемангиом печени // Врач. дело. 1980. № 5. С. 49-50.
  32. Aseni К., Riolo F., Cerrai F.G. et al. Hepatic hemangiomas: selection of criteria for surgical treatment // AJR. 1987. Vol. 42. P. 469-473.
  33. Rohner A. Traitment des tumeurs benighes du foie // Sscbweiz. Med. Wschr. 1986. Bd. 116. S. 1044-1050.

Copyright (c) 2014 Polyaev Y.A., Narbutov A.G., Myl'nikov A.A., Garbuzov R.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies