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Short bowel syndrome (SBS) continue to be important clinical problem in pediatric population due to high mortality and morbidity rates, as well as their devastating socioeconomic effects. In this paper, the etiology of SBS, its pathophysiology, the cellular and molecular mechanisms of intestinal adaptation, are reviewed. The most common complications of SBS are outlined with strategies to reduce them. The medical management and nutritional support of a patient with SBS is complex and requires a multidisciplinary. A review of the pharmacologic agents and growth factors that have been studied experimentally and administered clinically for the management of short bowel syndrome is presented.
Surgical procedures to promote intestinal adaptation and intestinal lengthening have largely changed the available options for non-transplant interventions.

About the authors

I. G. Sukhotnik

The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Dept of Pediatric Surgery, Bnai Zion Medical Center

Author for correspondence.
Профессор Израильского Института Технологии, Медицинский Факультет имени Руфи и Брюса Раппопорт, Кафедра детской хирургии, Медицинский Центр Бней-Цион, Хайфа, Израиль. Dept Pediatric Surgery B, BnaiZionMedicalCenter 47 Golomb St., P.O.B. 4940, Haifa, 31048, Israel. Ph (h): 972-4-8256815, Ph (b): 972-4-8359647, Fax-972-4-8359620. Israel


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