Abstract
The purpose of this research is to assess the efficiency of the original technology based on combining fresh autologous skin cells and fibrin glue in treating 2nd and 3d degree burns. This technology was used in 104 children with the burn area from 10 to 80% of the body surface, who received treatment in the burn centre of Privolzhsky Federal Medical Research Center of the Ministry of Health of Russia. The status of patients and their wounds was assessed using clinical observation, visual characterizing of the wound surface, photo registration, planimetry, IR imaging, and laser doppler flowmetry. The cell material was characterized using microscopic methods, specifying cell viability and concentration. Cell phenotype was determined by the cytofluorometry method. For 2nd degree burns, cell suspension and fibrin glue were applied directly to the wound after a primary toilet; for 3d degree burns - to the wound bed formed after an early necrectomy. The use of this technology made it possible to reduce the number of dressings and improve the quality of a newly formed skin integument in treating 2nd and 3d degree burns. The developed method is effective, safe and requires no additional costs; it can be used in any surgical hospital.
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