Robot-Assisted Thoracoscopic Resection of Thymus in a Child with Thymic Cyst

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Thymic cysts are rare lesions of the thymus gland. Open surgical resection is associated with trauma and may lead to postoperative complications such as pain, blood loss, and wound infection. Over the past decades, minimally invasive surgical techniques have been actively developed. The authors conducted a retrospective review of the medical history of a 15-year-old adolescent with a thymic cyst accompanied by exertional pain. The final diagnosis was established using contrast-enhanced computed tomography of the chest. The surgical intervention was performed using a robot-assisted technique. The Versius surgical robot (Cambridge Medical Robotics, UK) was used. Partial thymectomy of the left lobe was employed as the surgical technique. Following adhesiolysis between the tumor and the upper lobe of the left lung, adequate visualization of the tumor was achieved. The inferior horn of the thymus, together with the cyst, was isolated. The thymic tissue at the level of the left upper horn was then transected at the border of healthy tissue and extracted from the thoracic cavity through an enlarged incision at the assistant port site using an Endocatch bag. The operation was successfully performed without intraoperative difficulties or complications, with total duration was 120 minutes. Of this, 20 minutes were required for docking the robot. The procedure was fully robot-assisted with no conversion to thoracoscopic or open surgery. Histological examination revealed a cyst wall lined with simple squamous epithelium and filled with detritus showing signs of infection. The patient remained in the intensive care unit for 20 hours. Tracheal extubation was performed shortly after surgery, and the patient was discharged home on postoperative day 12. The chest drain was removed by the end of the first postoperative day. Robot-assisted thoracoscopic partial thymectomy is a safe and effective minimally invasive approach for the treatment of congenital thymic cysts, which is accompanied by a favorable postoperative course.

Full Text

Restricted Access

About the authors

Yuri A. Kozlov

Children’s Regional Clinical Hospital; Irkutsk State Medical Academy of Postgraduate Education; Irkutsk State Medical University

Email: yuriherz@hotmail.com
ORCID iD: 0000-0003-2313-897X
SPIN-code: 3682-0832

MD, Dr. Sci. (Medicine), Professor, Corresponding Member of the Russian Academy of Sciences

Россия, Irkutsk; Irkutsk; Irkutsk

Alexander P. Rozhansky

Children’s Regional Clinical Hospital; Irkutsk State Medical Academy of Postgraduate Education

Author for correspondence.
Email: alexanderozhanski@mail.ru
ORCID iD: 0000-0001-7922-7600
SPIN-code: 4012-7120
Россия, Irkutsk; Irkutsk

Simon S. Poloyan

Children’s Regional Clinical Hospital; Irkutsk State Medical University

Email: simonpoloyan@ya.ru
ORCID iD: 0000-0001-7042-6646
Россия, Irkutsk; Irkutsk

Eduard V. Sapukhin

Children’s Regional Clinical Hospital

Email: sapukhin@yandex.ru
ORCID iD: 0000-0001-5470-7384
Россия, Irkutsk

Alexey S. Strashinsky

Children’s Regional Clinical Hospital

Email: leksus-642@yandex.ru
ORCID iD: 0000-0002-1911-4468
SPIN-code: 9210-5286
Россия, Irkutsk

Marina V. Makarochkina

Children’s Regional Clinical Hospital

Email: m.makarochkina@gmail.com
SPIN-code: 4600-4071
Россия, Irkutsk

Anna O. Ryakhina

Children’s Regional Clinical Hospital

Email: romahka@yandex.ru
ORCID iD: 0009-0006-0340-1186
Россия, Irkutsk

Julia P. Syemschikova

Irkutsk State Medical University

Email: jsemshikova@mail.ru
SPIN-code: 1536-0612
Россия, Irkutsk

References

  1. Duwe BV, Sterman DH, Musani AI. Tumors of the mediastinum. Chest. 2005;128(4):2893–2909. doi: 10.1378/chest.128.4.2893
  2. Davis JW, Florendo FT. Symptomatic mediastinal thymic cysts. Ann Thorac Surg. 1988;46(6):693–694. doi: 10.1016/s0003-4975(10)64738-8
  3. Bacha EA, Chapelier AR, Macchiarini P, et al. Surgery for invasive primary mediastinal tumors. Ann Thorac Surg. 1998;66(1):234–239. doi: 10.1016/s0003-4975(98)00350-6
  4. Imielski B, Kurihara C, Manerikar A, et al. Comparative effectiveness and cost-efficiency of surgical approaches for thymectomy. Surgery. 2020;168(4):737–742. doi: 10.1016/j.surg.2020.04.037
  5. Hess NR, Sarkaria IS, Pennathur A, et al. Minimally invasive versus open thymectomy: a systematic review of surgical techniques, patient demographics, and perioperative outcomes. Ann Cardiothorac Surg. 2016;5(1):1–9. doi: 10.3978/j.issn.2225-319X.2016.01.01
  6. Friedant AJ, Handorf EA, Su S, Scott WJ. Minimally invasive versus open thymectomy for thymic malignancies: Systematic review and meta-analysis. J Thorac Oncol. 2016;11(1):30–38. doi: 10.1016/j.jtho.2015.08.004
  7. Shen C, Li J, Li J, Che G. Robot-assisted thoracic surgery versus video-assisted thoracic surgery for treatment of patients with thymoma: A systematic review and meta-analysis. Thorac Cancer. 2022;13(2):151–161. doi: 10.1111/1759-7714.14234
  8. Mlika M, Gattoufi W, Zribi H, et al. A unilocular thymic cyst associated with true thymic hyperplasia: a challenging diagnosis especially in a child. Int Med Case Rep J. 2015;8:215–218. doi: 10.2147/IMCRJ.S84144
  9. Zhu L-f, Zhang L-m, Zuo C-j, et al. Robot versus video-assisted thoracoscopic thymectomy for large thymic epithelial tumors: a propensity-matched analysis. BMC Surg. 2023;23(1):330. doi: 10.1186/s12893-023-02228-8
  10. Bennett B, Rentea RM. Thymectomy. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2024. PMID: 33231972
  11. McElyea S, Rafter J, Khan AW, et al. A case of cervico-mediastinal thymic cyst causing tracheal compression in a child. Kans J Med. 2020;13(1):77–78. doi: 10.17161/kjm.v13i1.13624
  12. Liu D, Ellis H. The mystery of the thymus gland. Clin Anat. 2016;29(6):679–684. doi: 10.1002/ca.22724
  13. Remien K, Jan A. Anatomy, head and neck, thymus. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2023. PMID: 30969570
  14. Srivalli M, Qaiyum HA, Srinivas Moorthy PN, Srikanth K. A case report of cervical thymic cyst and review of literature. Indian J Otolaryngol Head Neck Surg. 2011;63(1):93–95. doi: 10.1007/s12070-010-0092-7
  15. Suster S, Rosai J. Multilocular thymic cyst: an acquired reactive process. Study of 18 cases. Am J Surg Pathol. 1991;15(4):388–398. doi: 10.1097/00000478-199104000-00008
  16. Hatano H, Sumiya R, Misumi K, et al. Multilocular thymic cyst detected during COVID-19 treatment in an HIV-positive adult man: A case report and literature review. Exp Ther Med. 2023;25(6):285. doi: 10.3892/etm.2023.11984
  17. Choi YW, McAdams HP, Jeon SC, et al. Idiopathic multilocular thymic cyst: CT features with clinical and histopathologic correlation. Am J Roentgenol. 2001;177(4):881–885. doi: 10.2214/ajr.177.4.1770881
  18. Nomori H, Horio H, Suemasu K, et al. A case of rapidly enlarging unilocular thymic cyst. J Clin Pathol. 2002;55(8):636–637. doi: 10.1136/jcp.55.8.636
  19. Modh A, Rimner A, Allen PK, et al. Treatment modalities and outcomes in patients with advanced invasive thymoma or thymic carcinoma: A retrospective multicenter study. Am J Clin Oncol. 2016;39(2):120–125. doi: 10.1097/COC.0000000000000024
  20. Cooper JD. History of thymectomy for myasthenia gravis. Thorac Surg Clin. 2019;29(2):151–158. doi: 10.1016/j.thorsurg.2018.12.011
  21. Seong YW, Kang CH, Choi J-W, et al. Early clinical outcomes of robot-assisted surgery for anterior mediastinal mass: its superiority over a conventional sternotomy approach evaluated by propensity score matching. Eur J Cardiothorac Surg. 2014;45(3):e68–e73. doi: 10.1093/ejcts/ezt557
  22. Odaka M, Tsukamoto Y, Shibasaki T, et al. Thoracoscopic thymectomy is a feasible and less invasive alternative for the surgical treatment of large thymomas. Interact Cardiovasc Thorac Surg. 2017;25(1):103–108. doi: 10.1093/icvts/ivx048
  23. Marulli G, Rea F, Melfi F, et al. Robot-aided thoracoscopic thymectomy for early-stage thymoma: a multicenter European study. J Thorac Cardiovasc Surg. 2012;144(5):1125–1130. doi: 10.1016/j.jtcvs.2012.07.082
  24. Casiraghi M, Galetta D, Borri A, et al. Robotic-assisted thymectomy for early-stage thymoma: a propensity-score matched analysis. J Robot Surg. 2018;12(4):719–724. doi: 10.1007/s11701-018-0816-3
  25. Kneuertz PJ, Kamel MK, Stiles BM, et al. Robotic thymectomy is feasible for large thymomas: A propensity-matched comparison. Ann Thorac Surg. 2017;104(5):1673–1678. doi: 10.1016/j.athoracsur.2017.05.074
  26. Agatsuma H, Yoshida K, Yoshino I, et al. Video-assisted thoracic surgery thymectomy versus sternotomy thymectomy in patients with thymoma. Ann Thorac Surg. 2017;104(3):1047–1053. doi: 10.1016/j.athoracsur.2017.03.054
  27. Jiang B, Tan Q-Y, Deng B, et al. Robot-assisted thymectomy in large anterior mediastinal tumors: A comparative study with video-assisted thymectomy and open surgery. Thorac Cancer. 2023;14(3):267–273. doi: 10.1111/1759-7714.14744
  28. O’Sullivan KE, Kreaden US, Hebert AE, et al. A systematic review of robotic versus open and video assisted thoracoscopic surgery (VATS) approaches for thymectomy. Ann Cardiothorac Surg. 2019;8(2):174–193. doi: 10.21037/acs.2019.02.04
  29. Chiba Y, Miyajima M, Takase Y, et al. Robot-assisted and video-assisted thoracoscopic surgery for thymoma: comparison of the perioperative outcomes using inverse probability of treatment weighting method. Gland Surg. 2022;11(8):1287–1300. doi: 10.21037/gs-22-333
  30. Şehitogullari A, Nasır A, Anbar R, et al. Comparison of perioperative outcomes of videothoracoscopy and robotic surgical techniques in thymoma. Asian J Surg. 2020;43(1):244–250. doi: 10.1016/j.asjsur.2019.04.005
  31. Ye B, Tantai J-C, Li W, et al. Video-assisted thoracoscopic surgery versus robotic-assisted thoracoscopic surgery in the surgical treatment of Masaoka stage I thymoma. World J Surg Oncol. 2013;11:157. doi: 10.1186/1477-7819-11-157
  32. Bagatelia ZA, Parshin VD, Grekov DN, et al. Robotic and thoracoscopic surgeries for anterior mediastinal neoplasms. Pirogov Russian Journal of Surgery. 2025;(2):6–12. doi: 10.17116/hirurgia20250216 EDN: XYIDPT

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig. 1. Contrast-enhanced computed tomography of the chest. The thymic cyst is indicated by an arrow.

Download (50KB)
3. Fig. 2. Robot-assisted thoracoscopic partial thymectomy: a, stage of dissection of thymic tissue from the lung; b, stage of isolation of the thymic cyst; c, stage of transection of the thymic tissue at the level of the left upper horn.

Download (492KB)

Copyright (c) 2025 Eco-Vector

License URL: https://eco-vector.com/for_authors.php#07

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: ПИ № ФС 77 - 81892 от 24.09.2021 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies