MESENCHYMAL HAMARTOMA OF THE LIVER

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Abstract

In this paper, we report a case of a giant fast-growing cystic tumor of the liver in an eight-month-old child. Abdominal ultrasound and computed tomography performed in the preoperative stage revealed a mesenchymal hamartoma of the liver. The tumor was removed completely. Histological examination confirmed the mesenchymal hamartoma. Such a benign liver lesion is a very rare case. We are including the data highlighting the issues of etiology, pathogenesis and diagnostics of hamartomas of the liver in children.

About the authors

A. Yu. Razumovsky

N.F. Filatov Children City Clinical Hospital No. 13

Author for correspondence.
Email: 1595105@mail.ru
Russian Federation

E. V. Feoktistova

Federal Scientific Clinical Research Center of Pediatric Hematology, Oncology, and Immunology named by Dmitry Rogachev of the Ministry of Health of the Russian Federation

Email: 9433672@mail.ru
Russian Federation

D. Yu. Kachanov

Federal Scientific Clinical Research Center of Pediatric Hematology, Oncology, and Immunology named by Dmitry Rogachev of the Ministry of Health of the Russian Federation

Email: kachanov78@gmail.com
Russian Federation

G. V. Tereschenko

Federal Scientific Clinical Research Center of Pediatric Hematology, Oncology, and Immunology named by Dmitry Rogachev of the Ministry of Health of the Russian Federation

Email: inkova@mail.ru
Russian Federation

N. V. Kulikova

N.F. Filatov Children City Clinical Hospital No. 13

Email: noemail@neicon.ru
Russian Federation

R. A. Moiseenko

Federal Scientific Clinical Research Center of Pediatric Hematology, Oncology, and Immunology named by Dmitry Rogachev of the Ministry of Health of the Russian Federation

Email: Roman.Moiseenko@fccho-moscow.tu
Russian Federation

O. Yu. Isotova

Federal Scientific Clinical Research Center of Pediatric Hematology, Oncology, and Immunology named by Dmitry Rogachev of the Ministry of Health of the Russian Federation

Email: Olga.Izotova@fccho-moscow.tu
Russian Federation

V. Yu. Roschin

Federal Scientific Clinical Research Center of Pediatric Hematology, Oncology, and Immunology named by Dmitry Rogachev of the Ministry of Health of the Russian Federation

Email: vitally.roshin@fccho-moscow.tu
Russian Federation

S. R. Varfolomeeva

Federal Scientific Clinical Research Center of Pediatric Hematology, Oncology, and Immunology named by Dmitry Rogachev of the Ministry of Health of the Russian Federation

Email: varfolomeeva-07@mail.ru
Russian Federation

References

  1. Das C.J., Dhingra S., Gupta A.K. et al. Imaging of pediatric liver tumors with pathologic correlation // Clin. radiology. 2009. Vol. 5. Р. 1015-1025.
  2. Edmondson H.A. Differential diagnosis of tumors and tumor like lesions of liver in infancy and childhood // Am. J. Dis. Child. 1956. Vol. 91. Р. 168-186.
  3. deMaioribus C.A., Lally K.P., Sim K. et al. Mesenchymal hamartoma of the liver. A 35-years review // Arch. Surg. 1990. Vol. 125. Р. 598-600.
  4. Murray J.D., Ricketts R.R. Mesenchymal hamartoma of the liver // Am. Surg. 1998. Vol. 64. Р. 1097-1103.
  5. Yen J.B., Kong M.S., Lin J.N. Hepatic mesenchymal hamartoma // J. Paediatr. Clin. Health. 2003. Vol. 39. Р. 632-634.
  6. Dickinson J.E., Knowles S., Phillips J.M. Prenatal diagnosis of hepatic mesenchymal hamartoma // Prenat. Diagn. 1999. Vol. 19. Р. 81-84.
  7. Laberge J.M., Patenaude Y., Desilets V. et al. Large hepatic mesenchymal hamartoma leading to mid-trimester fetal demise // Fetal. Diagn. Ther. 2005. Vol. 20. Р. 141-145.
  8. Kitano Y., Ruchelli E., Weiner S. et al. Hepatic mesenchymal hamartoma associated with mesenchymal stem villous hyperplasia of the placenta // Fetal. Diagn. Ther. 2000. Vol. 15. Р. 134-138.
  9. Lennington W.J., Gray G.F., Page D.L. Mesenchymal hamartoma of liver: a regional ischemic lesion of a sequestrated lobe // Am.J. Dis. Child. 1993. Vol. 147. Р. 193-196.
  10. Ehren H., Mahour G.H., Isaacs Jr. H. Benign liver tumors in infancy and childhood: a report of 48 cases // Am. J. Surg. 1983. Vol. 145. Р. 325-329.
  11. Mulrooney D.A., Carpenter B., Georgieff M. et al. Hepatic mesenchymal hamartoma in a neonate: a case report and a review of the literature // J. Pediatr. Hematol. Oncol. 2001. Vol. 23. Р. 316-327.
  12. Rao S.P., Bhagavath S., Chen C.K. et al. Mesenchymal hamartoma of the liver in an older child: association with disseminated intravascular coagulation // Med. Pediatr. Oncol. 1984. Vol. 12. Р. 112-115.
  13. Papastratis J., Margaris H., Zofragos G.N. et al. Mesenchymal hamartoma of the liver in an adult: a review of the literature // Int.J. Clin. Pract. 2000. Vol. 54. P. 552-554.
  14. Teele R.L., Pease P.W., Rowley R.S. Malrotation in newborns following antenatal diagnosis of intra-abdominal cyst // Pediatr. Radiol. 1998. Vol. 28. Р. 717-721.
  15. Justrabo E., Martin L., Yaziji N. et al. L’hamartome mesenhimateux du foie de l’enfant. Etitude immunohistochimique, ultrastructirale et en cytometry en flux d’un cas // Gastoenterol. Clin. Biol. 1998. Vol. 22. Р. 964-968.
  16. Boman F., Bossard C., Fabre M. et al. Mesenchymal hamartomas of the liver may be associated with increased alpha fetoprotein concentrations and mimic hepatoblastomas // Eur.J. Pediatr. Surg. 2004. Vol. 14. Р. 63-66.
  17. Kenney I.J., Hendry G.M. A., Mackinlay G.A. Spontaneous regression of mesenchymal hamartoma: observations using ultrasound // J. Clin. Ultrasound. 1986. Vol. 14. Р. 72-76.
  18. Mansour A., Quandeel M., Sughayer M. et al. Solid (stromal predominance) hepatic mesenchymal hamartoma // Pediatr. Radiol. 2005. Vol. 35. Р. 349-350.
  19. Kim S.N., Kim W.S., Cheon J.E. et al. Radiological spectrum oh hepatic mesenchymal hamartoma in children // Korean. J. Radiol. 2007. Vol. 8. Р. 498-505.
  20. Kele P.G., van der Jagt E.J. Diffusion weighted imaging in the liver // World J. Gastroenterol. 2010. Vol. 16. Р. 1567-1576.
  21. Fowler K.J., Brown J.J., Narra V.R. Magnetic resonance imaging of focal liver lesions: approach to imaging diagnosis // Hepatology. 2011. Vol. 54. Р. 2227-2237.
  22. Lantiga M.A., Gevers T.J. G., Drenth J.P. H. Evaluation of hepatic cystic lesions // World J. Gastroenterol. 2013. Vol. 19. Р. 3543-3554.
  23. Teoh A.Y., Ng S.S., Lee K.F et al. Biliary cystadenoma and other complicated cystic lesions of the liver: diagnostic and therapeutic challenges // World J. Surg. 2006. Vol. 30. Р. 1560-1566.
  24. Pinto M.M., Kaye A.D. Fine needle aspiration of cystic liver lesions. Cytologic examination and carcinoembryonic antigen assay of cyst content // Acta Cytol. 1989. Vol. 33. Р. 852-856.
  25. van Keimpema L., de Konig D.B., van Hoek B. et al. Patients with isolated polycystic liver disease referred to liver centers: clinical characterization of 137 cases // Liver Int. 2011. Vol. 31. Р. 92-98.
  26. The liver, gallbladder and biliary tract // Pediatric Pathology / J.T. Stocker, L.P. Dehner (eds). - Philadelphia: Williams and Wilkins, 2002. Р. 757-760.
  27. Abdulkader I., Fraga M., Perez-Becerra E. et al. Mesenchymal hamartoma of the liver. Clinicopathological, immunohistochemical and flow cytometric study of two cases // Hepatol. Res. 2004. Vol. 28. Р. 216-219.
  28. Shintaku M., Watanabe K. Mesenchymal hamartoma of the liver: a proliferative lesion of possible hepatic stellate cell (Ito cell) origin // Pathol. Res. Pract. 2010. Vol. 206. Р. 532-536.
  29. von Schweinitz D., Dammeier B.G., Gluer S. Mesenchymal hamartoma of the liver - new insight in histogenesis // J. Pediatr. Surg. 1999. Vol. 34. Р 1269-1271.
  30. Ramanujam T.M., Ramesh J.C., Goh D.W. et al. Malignant transformation of mesenchymal hamartoma of the liver: case report and review of the literature // J. Pediatr. Surg. 1999. Vol. 34. Р. 1684-1686.
  31. Bartho S., Schulz H.J., Bollman R. et al. Prenatally diagnosed mesenchymal hamartoma of the liver // Zentralbl. Pathol. 1992. Vol. 138. Р. 141-144.
  32. Alomari A.I. Comments on imaging and management of hepatic hemangiomas // Pediatr. Radiol. 2009. Vol. 39. Р. 637-638.
  33. Marsciani A., Pericoli R., Alaggio R. et al. Massive response of severe infantile hemangioma to propranolol // Pediatr. Blood Cancer. 2008. Vol. 54. Р. 176-178.
  34. Hernandez F., Navarro M., Encinas J.Z. et al. The role of GLUT1 immunostaining in the diagnosis and classification of liver vascular tumors in children // J. Pediatr. Surg. 2005. Vol. 40. Р. 801-804.
  35. Varich L. Ultrasound of pediatric liver masses // Ultrasound Clin. 2010. Vol. 5. Р. 137-152.
  36. Stocker J.T., Ishak K.G. Undifferentiated (embryonal) sarcoma of the liver. Report of 31 cases // Cancer. 1978. Vol. 42. Р. 336-348.
  37. Otani Y., Takayasu H., Ishimaru Y. et al. Secretion and expression of epithelial markers supports the biliary origin of solitary nonparasitic cyst of the liver in infancy // J. Pediatr. Surg. 2005. Vol. 40. E27 - E30.
  38. Thompson P.A. Chintagumpala M. Renal and hepatic tumors in the neonatal period // Semin. Fetal. Neonatal. Med. 2012. Vol. 17. Р. 216-221.
  39. Okeda R. Mesenchymal hamartoma of the liver - an autopsy case with serial sections and some comments on its pathogenesis // Acta Path. Jpn. 1976. Vol. 26. Р. 229-236.
  40. Bove K.E., Blough R.I., Soukup S. Third report of t (19q) (13.4) in mesenchymal hamartoma of the liver with comments on link to embryonal sarcoma of the liver // Pediatric. Dev. Pathol. 1998. Vol. 1. Р. 438-442.
  41. Hu X., Chen H., Jin M. et al. Molecular cytogenetic characterization of undifferented embryonal sarcoma of the liver: a case report and literature review // Mol. Cytogenetic. 2012. Vol. 5. Р. 26-27.
  42. Otal T.M., Hendricks J.B., Pharis P et al. Mesenchymal hamartoma of the liver: DNA flow cytometric analysis of eight cases // Cancer. 1994. Vol. 74. Р. 1237-1242.
  43. von Schweinitz D. Neonatal liver tumors // Semin. Neonatol. 2003. Vol. 8. Р. 403-410.
  44. Virgone C., Cecchetto G., Dall’igna P. et al. Mesenchymal hamartoma of the liver in older children: an adult variant or a different entity? Report of a case with review of a literature // Appl. Immunohistchem. Mol Morphol. 2012 [Epub ahead of print].
  45. Sherata B.M., Gupta N.A., Katzenstein H.M. et al. Undifferetiated embryonal sarcoma of the liver is associated with mesenchymal hamartoma and multiple chromosomal abnormalities: a review of eleven cases // Pediatr. Dev. Pathol. 2011. Vol. 14. Р. 111-116.
  46. Meyers R.L. Tumors of the liver in children // Surg. Oncol. 2007. Vol. 16. Р. 195-203.
  47. Karpolowsky J.S., Pansini A., Lazarus C. et al. Difficulties in the management of mesenchymal hamartomas // Pediatr. Surg. Int. 2008. Vol. 24. Р. 1171-1175.
  48. Fabre M., Yilmaz F., Buendia M.A. Hepatic tumors in childhood: experience on 245 tumors and review of a literature // Ann. Pathol. 2004. Vol. 24. Р. 536-555.
  49. Alwaidh M.H., Woodhall C.R., Carty H.T. Mesenchymal hamartoma of the liver: a case report // Pediatr Radiol. 1997. Vol. 27. Р. 247-249.
  50. Alkalay A.L., Puri A.R., Pomerance J.J. et al. Mesenchymal hamartoma of the liver responsive to cyclophosphamide therapy: therapeutic approach // J. Pediatr. Surg. 1985. Vol. 20. Р. 125-128.
  51. Silber D.L., Soper R.T., Kent T.H. Life-threatening mesenchymal hamartoma of the liver // J. Pediatr. Surg. 1970. Vol. 5. Р. 471-472.

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Copyright (c) 2015 Razumovsky A.Y., Feoktistova E.V., Kachanov D.Y., Tereschenko G.V., Kulikova N.V., Moiseenko R.A., Isotova O.Y., Roschin V.Y., Varfolomeeva S.R.

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