USAGE OF SELECTIVE β1-BLOCKER ATENOLOL IN CHILDREN WITH A SEVERE BURN TRAUMA

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Abstract

Relevancy: hypermetabolic response caused by the increased level of catecholamines accompanies a severe burn trauma, whereas β-adrenoblockers, decreasing the action of endogenous catecholamines, enable to reduce the load on the myocardium and decrease the pronounced symptoms of hypermetabolism. Purpose of the study: determination of the possibility and safety of using β1-blocker of atenolol in children in hyperdynamic phase of the burn damage accompanied by tachycardia and arterial hypertension. Materials and methods: the prospective open randomized study included 24 children with a burn trauma on the total body surface area (TBSA) from 30 to 80% accompanied by the hyperdynamic type of hemodynamics (cardiac index > 6 l/min/m2) aged 6 to 18 admitted to the department of resuscitation and intensive therapy of G.N. Speransky Children’s State Clinical Hospital No. 9, Moscow, from January 1, 11 to December 31, 15. Selective β1-blocker of atenolol at 4 mg/kg/day is added to the therapy of the basic group and intensive therapy without β1-blockers is intended for the control group. The study lasts 5 days. Results: in the studies they used selective β1- blocker of atenolol and in foreign clinics they use propranolol for these purposes. We managed to decrease the heart rate for 20-25% of the initial one but the tendency to tachycardia preserved during the entire study. Recovery of arterial pressure, systolic output index and DO2I was observed which indicates at the decrease of hypermetabolism. No complications were observed.

About the authors

D. K. Azovsky

G.N. Speransky Children’s State Clinical Hospital No. 9, Health Department of Moscow

Author for correspondence.
Email: Dmitry.azovskiy@gmail.com
Russian Federation

A. U. Lekmanov

G.N. Speransky Children’s State Clinical Hospital No. 9, Health Department of Moscow; N.I. Pirogov Russian National Research Medical University

Email: aulek@rambler.ru
Russian Federation

S. F. Pilyutik

G.N. Speransky Children’s State Clinical Hospital No. 9, Health Department of Moscow

Email: spilyutik@gmail.com
Russian Federation

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Copyright (c) 2016 Azovsky D.K., Lekmanov A.U., Pilyutik S.F.

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