<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="brief-report" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский вестник детской хирургии, анестезиологии и реаниматологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2219-4061</issn><issn publication-format="electronic">2587-6554</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">999</article-id><article-id pub-id-type="doi">10.17816/psaic999</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Discussions</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Дискуссии</subject></subj-group><subj-group subj-group-type="article-type"><subject>Short Communication</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Reply to the Commentary on the article “Sepsis in children: federal guidelines (draft)” I.А. Savin</article-title><trans-title-group xml:lang="ru"><trans-title>Ответ на Комментарий к статье «Сепсис у детей: федеральные клинические рекомендации (проект)» И.А. Савина</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0798-1625</contrib-id><contrib-id contrib-id-type="spin">3630-5061</contrib-id><name-alternatives><name xml:lang="en"><surname>Lekmanov</surname><given-names>Andrey U.</given-names></name><name xml:lang="ru"><surname>Лекманов</surname><given-names>Андрей Устинович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>aulek@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1473-1982</contrib-id><contrib-id contrib-id-type="spin">6694-6714</contrib-id><name-alternatives><name xml:lang="en"><surname>Popov</surname><given-names>Dmitry А.</given-names></name><name xml:lang="ru"><surname>Попов</surname><given-names>Дмитрий Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>д-р мед. наук</p></bio><email>da_popov@inbox.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Pirogov Russian Research Medical University</institution></aff><aff><institution xml:lang="ru">Российский научно-исследовательский медицинский университет им. Н.И. Пирогова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Bakulev National Medical Research Center for Cardiovascular Surgery</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр сердечно-сосудистой хирургии им. А.Н. Бакулева</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-10-13" publication-format="electronic"><day>13</day><month>10</month><year>2021</year></pub-date><volume>11</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>413</fpage><lpage>416</lpage><history><date date-type="received" iso-8601-date="2021-09-09"><day>09</day><month>09</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-09-09"><day>09</day><month>09</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Lekmanov A.U., Popov D.А.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, Лекманов А.У., Попов Д.А.</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Lekmanov A.U., Popov D.А.</copyright-holder><copyright-holder xml:lang="ru">Лекманов А.У., Попов Д.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://rps-journal.ru/jour/article/view/999">https://rps-journal.ru/jour/article/view/999</self-uri><abstract xml:lang="en"><p>The authors of the Clinical Guidelines are grateful to Professor I.A. Savin for his comments and provide answers to the comments made regarding the appointment of antibacterial drugs and immunoglobulins for sepsis in children.</p></abstract><trans-abstract xml:lang="ru"><p>Авторы Клинических рекомендаций благодарят профессора И.А. Савина за его комментарии и приводят ответы на высказанные замечания, касающиеся назначения антибактериальных препаратов и иммуноглобулинов при сепсисе у детей.</p></trans-abstract><kwd-group xml:lang="en"><kwd>sepsis</kwd><kwd>clinical guidelines</kwd><kwd>children</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>сепсис</kwd><kwd>клинические рекомендации</kwd><kwd>дети</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Weiss SL, Peters MJ, Alhazzani W, et al. Surviving Sepsis Campaign International Guidelines for the Management Sepsis and Septic Shock and Sepsis-associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020;21(2):e52–e106. DOI: 10.1097/PCC.0000000000002198</mixed-citation><mixed-citation xml:lang="ru">Weiss S.L., Peters M.J., Alhazzani W., et al. Surviving Sepsis Campaign International Guidelines for the Management Sepsis and Septic Shock and Sepsis-associated Organ Dysfunction in Children // Pediatr Crit Care Med. 2020. Vol. 21. No. 2. P. e52–e106. DOI: 10.1097/PCC.0000000000002198</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">El-Nawawy A, El-Kinany H, Hamdy El-Sayed M, Boshra N. Intravenous polyclonal immunoglobulin administration to sepsis syndrome patients: a prospective study in a pediatric intensive care unit. J Trop Pediatr. 2005;51(5):271-278. DOI: 10.1093/tropej/fmi011</mixed-citation><mixed-citation xml:lang="ru">El-Nawawy A., El-Kinany H., Hamdy El-Sayed M., Boshra N. Intravenous polyclonal immunoglobulin administration to sepsis syndrome patients: a prospective study in a pediatric intensive care unit // J Trop Pediatr. 2005. Vol. 51. No. 5. P. 271–278. DOI: 10.1093/tropej/fmi011</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Ohlsson A, Lacy JB. Intravenous immunoglobulin for suspected or proven infection in neonates. Cochrane Database Syst Rev. 2013;(7):CD001239. DOI: 10.1002/14651858.CD001239.pub4. Corrected and republished from: Cochrane Database Syst Rev. 2015;(3):CD001239. DOI: 10.1002/14651858.CD001239.pub5</mixed-citation><mixed-citation xml:lang="ru">Ohlsson A., Lacy J.B. Intravenous immunoglobulin for suspected or proven infection in neonates // Cochrane Database Syst Rev. 2013. Vol. 2. No. 7. P. CD001239. DOI: 10.1002/14651858.CD001239.pub4. Corrected and republished from: Cochrane Database Syst Rev. 2015. No. 3. P. CD001239. DOI: 10.1002/14651858.CD001239.pub5</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">INIS Collaborative Group; Brocklehurst P, Farrell B, King A, et al. Treatment of neonatal sepsis with intravenous immune globulin. N Engl J Med. 2011;365(13):1201–1211. DOI: 10.1056/NEJMoa1100441</mixed-citation><mixed-citation xml:lang="ru">INIS Collaborative Group; Brocklehurst P., Farrell B., King A., et al. Treatment of neonatal sepsis with intravenous immune globulin // N Engl J Med. 2011. Vol. 29, No. 365(13). P. 1201–1211. DOI: 10.1056/NEJMoa1100441</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Beloborodova NV, Popov DA, Shatalov KV, et al. Zamestitel’naja immunoterapija pod kontrolem testa na prokal’citonin – novyj podhod k preduprezhdeniju manifestacii infekcii v posleoperacionnom periode u detej so slozhnymi vrozhdennymi porokami serdca. Heart and Vessels Diseases in Children. 2005;3:62–68. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Белобородова Н.В., Попов Д.А., Шаталов К.В., и др. Заместительная иммунотерапия под контролем теста на прокальцитонин — новый подход к предупреждению манифестации инфекции в послеоперационном периоде у детей со сложными врожденными пороками сердца // Детские болезни сердца и сосудов. 2005. Т. 3. С. 62–68.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Abdullayev E, Kilic O, Bozan G, et al. Clinical, laboratory features and prognosis of children receiving IgM-enriched immunoglobulin (3 days vs. 5 days) as adjuvant treatment for serious infectious disease in pediatric intensive care unit: a retrospective single-center experience (PIGMENT study). Human Vaccines &amp; Immunotherapeutics. 2020;16(8):1997–2002. DOI: 10.1080/21645515.2019.1711298</mixed-citation><mixed-citation xml:lang="ru">Abdullayev E., Kilic O., Bozan G., et al. Clinical, laboratory features and prognosis of children receiving IgM-enriched immunoglobulin (3 days vs. 5 days) as adjuvant treatment for serious infectious disease in pediatric intensive care unit: a retrospective single-center experience (PIGMENT study). Human Vaccines &amp; Immunotherapeutics. 2020. Vol. 16. No. 8. P. 1997–2002. DOI: 10.1080/21645515.2019.1711298</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Martinez J-I, Sánchez H-F, Velandia J-A, et al. Treatment with IgM-enriched immunoglobulin in sepsis: a matched case-control analysis. J Crit Care. 2021;64:120–124. DOI: 10.1016/j.jcrc.2021.03.015</mixed-citation><mixed-citation xml:lang="ru">Martinez J.-I., Sánchez H.-F., Velandia J.-A., et al. Treatment with IgM-enriched immunoglobulin in sepsis: a matched case-control analysis // J Crit Care. 2021. Vol. 64. P. 120–124. DOI: 10.1016/j.jcrc.2021.03.015</mixed-citation></citation-alternatives></ref></ref-list></back></article>
