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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский вестник детской хирургии, анестезиологии и реаниматологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2219-4061</issn><issn publication-format="electronic">2587-6554</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">988</article-id><article-id pub-id-type="doi">10.17816/psaic988</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Treatment of a patient with COVID-19 and adverse premorbid background: A case report</article-title><trans-title-group xml:lang="ru"><trans-title>Лечение пациентки с COVID-19 и неблагоприятным преморбидным фоном: клиническое наблюдение</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3220-9549</contrib-id><contrib-id contrib-id-type="spin">4131-3115</contrib-id><name-alternatives><name xml:lang="en"><surname>Tulokhonova</surname><given-names>Julia S.</given-names></name><name xml:lang="ru"><surname>Тулохонова</surname><given-names>Юлия Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>anesthesiologist-resuscitator</p></bio><bio xml:lang="ru"><p>врач анестезиолог-реаниматолог</p></bio><email>se_yu@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5541-7335</contrib-id><contrib-id contrib-id-type="spin">3953-2692</contrib-id><name-alternatives><name xml:lang="en"><surname>Obarchuk</surname><given-names>Oksana G.</given-names></name><name xml:lang="ru"><surname>Обарчук</surname><given-names>Оксана Геннадьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>anesthesiologist-resuscitator</p></bio><bio xml:lang="ru"><p>врач анестезиолог-реаниматолог</p></bio><email>oxya_ne@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1527-7005</contrib-id><contrib-id contrib-id-type="spin">1907-1447</contrib-id><name-alternatives><name xml:lang="en"><surname>Averina</surname><given-names>Irina A.</given-names></name><name xml:lang="ru"><surname>Аверина</surname><given-names>Ирина Анатольевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>anesthesiologist-resuscetator</p></bio><bio xml:lang="ru"><p>врач анестезиолог-реаниматолог</p></bio><email>nsaplina@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Ivano-Matryoninsk Children’s Hospital</institution></aff><aff><institution xml:lang="ru">Городская Ивано-Матренинская детская клиническая больница</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-10-13" publication-format="electronic"><day>13</day><month>10</month><year>2021</year></pub-date><volume>11</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>395</fpage><lpage>402</lpage><history><date date-type="received" iso-8601-date="2021-08-03"><day>03</day><month>08</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-08-12"><day>12</day><month>08</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Tulokhonova J.S., Obarchuk O.G., Averina I.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, Тулохонова Ю.С., Обарчук О.Г., Аверина И.А.</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Tulokhonova J.S., Obarchuk O.G., Averina I.A.</copyright-holder><copyright-holder xml:lang="ru">Тулохонова Ю.С., Обарчук О.Г., Аверина И.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://rps-journal.ru/jour/article/view/988">https://rps-journal.ru/jour/article/view/988</self-uri><abstract xml:lang="en"><p><bold><italic>BACKGROUND:</italic></bold> In the presence of severe comorbid pathology, children get sick with coronavirus disease 2019 (COVID-19) as severe as adults.</p> <p><bold><italic>CASE REPORT:</italic></bold> This paper describes the treatment of a 17-year-old patient with severe bilateral pneumonia caused by severe acute respiratory syndrome coronavirus 2 that damage a large volume of the lung tissue (69% on the right, 87.1% on the left, and grade IV lung lesions according to computed tomography) with an unfavorable premorbid background (grade IV obesity with a body mass index of 54.5 kg/m<sup>2</sup>, Down syndrome, moderate mental retardation, and primary hypothyroidism). The child was admitted to the hospital on day 10 of illness in an extremely serious condition. On admission, she received artificial lung ventilation and then high-flow mask ventilation with an oxygen flow of 12 L/min. In addition to respiratory support, she received etiotropic (hydroxychloroquine), anticoagulant (enoxaparin), antibacterial, (ceftriaxone), and antihypertensive treatments. Levothyroxine sodium was administered for hypothyroidism. Permanent monitoring of the acid–base balance, general and biochemical blood tests, and coagulography were performed. Gradual positive dynamics of the respiratory status was observed, and oxygen flow decreased. The case was constantly consulted to a pulmonologist, endocrinologist, and cardiologist, who corrected antihypertensive therapy depending on blood pressure indicators. Oxygen support was given for 13 days. After receiving a double-negative PCR test for COVID-19, the patient was transferred to the pulmonology department, from which she was discharged in satisfactory condition for outpatient observation.</p> <p><bold><italic>CONCLUSION:</italic></bold> Our patient with COVID-19, severe lung damage with a combination of comorbid pathologies, extremely unfavorable prognosis (grade IV obesity, Down syndrome, and hypothyroidism), who received active complex treatment in accordance with modern guidelines, recovered despite late admission to the hospital.</p></abstract><trans-abstract xml:lang="ru"><p><italic><bold>Введение.</bold> </italic>При наличии тяжелой коморбидной патологии дети болеют COVID-19 так же тяжело, как и взрослые.</p> <p><bold><italic>Описание наблюдения.</italic></bold> В работе представлено клиническое наблюдение за лечением 17-летней пациентки с тяжелой двусторонней пневмонией, вызванной SARS-CoV-2, при большом объеме поражения легочной ткани (справа 69 %, слева 87,1 %, IV степень поражения легких по данным компьютерной томографии) с неблагоприятным преморбидным фоном (ожирение IV степени с индексом массы тела 54,5 кг/м<sup>2</sup>, синдром Дауна, умеренная умственная отсталость; первичный гипотиреоз). Ребенок поступил в стационар на 10-е сутки заболевания в крайне тяжелом состоянии. В течение суток она находилась на искусственной вентиляции легких, затем переведена на высокопоточную масочную вентиляцию с потоком кислорода 12 л/мин. Кроме респираторной поддержки пациентка получала этиотропную (гидроксихлорохин), антикоагулянтную (эноксапарин), антибактериальную (цефтриаксон) гипотензивную терапию. По поводу гипотиреоза получала левотироксин натрия. Осуществлялся постоянный контроль кислотно-щелочного равновесия, общего и биохимического анализа крови, коагулограммы. По респираторному статусу отмечена постепенная положительная динамика, поток кислорода снижался. Постоянно консультировалась пульмонологом, эндокринологом и кардиологом, который проводил коррекцию гипотензивной терапии в зависимости от показателей артериального давления. Кислородная поддержка осуществлялась на протяжении 13 дней. После получения дважды отрицательного результата ПЦР-теста на COVID-19 пациентка переведена в отделение пульмонологии, из которого выписана в удовлетворительном состоянии под амбулаторное наблюдение.</p> <p><bold><italic>Заключение.</italic></bold> Пациентка с COVID-19 и тяжелым поражением легких с наличием крайне неблагоприятного в плане прогноза сочетания коморбидной патологии (ожирение 4-й степени, синдром Дауна, гипотиреоз), получив активное комплексное лечение в соответствии с современными разработками, выздоровела, несмотря на позднее поступление в стационар.</p></trans-abstract><kwd-group xml:lang="en"><kwd>novel coronavirus infection COVID-19</kwd><kwd>pneumonia</kwd><kwd>obesity</kwd><kwd>Down syndrome</kwd><kwd>children</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>новая коронавирусная инфекция COVID-19</kwd><kwd>пневмония</kwd><kwd>ожирение</kwd><kwd>синдром Дауна</kwd><kwd>дети</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Berlin DA, Gulick RM, Martinez FJ. 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