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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский вестник детской хирургии, анестезиологии и реаниматологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2219-4061</issn><issn publication-format="electronic">2587-6554</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1926</article-id><article-id pub-id-type="doi">10.17816/psaic1926</article-id><article-id pub-id-type="edn">KFWFWU</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original Study Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Retrograde intrarenal surgery using a flexible ureterorenoscope in children with urolithiasis</article-title><trans-title-group xml:lang="ru"><trans-title>Ретроградная интраренальная хирургия с использованием гибкого уретерореноскопа у детей с мочекаменной болезнью</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>儿童尿路结石病的柔性输尿管肾镜逆行肾内手术</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9081-8321</contrib-id><contrib-id contrib-id-type="spin">3964-1815</contrib-id><name-alternatives><name xml:lang="en"><surname>Surov</surname><given-names>Roman V.</given-names></name><name xml:lang="ru"><surname>Суров</surname><given-names>Роман Викторович</given-names></name><name xml:lang="zh"><surname>Surov</surname><given-names>Roman V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>rimvs@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0785-0222</contrib-id><contrib-id contrib-id-type="spin">1228-5484</contrib-id><name-alternatives><name xml:lang="en"><surname>Shmyrov</surname><given-names>Oleg S.</given-names></name><name xml:lang="ru"><surname>Шмыров</surname><given-names>Олег Сергеевич</given-names></name><name xml:lang="zh"><surname>Shmyrov</surname><given-names>Oleg S.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>moroz-uro@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1892-7328</contrib-id><contrib-id contrib-id-type="spin">9632-8895</contrib-id><name-alternatives><name xml:lang="en"><surname>Lazishvili</surname><given-names>Marina N.</given-names></name><name xml:lang="ru"><surname>Лазишвили</surname><given-names>Марина Николаевна</given-names></name><name xml:lang="zh"><surname>Lazishvili</surname><given-names>Marina N.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>pedurology@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6758-2442</contrib-id><contrib-id contrib-id-type="spin">7887-3930</contrib-id><name-alternatives><name xml:lang="en"><surname>Kulaev</surname><given-names>Artur V.</given-names></name><name xml:lang="ru"><surname>Кулаев</surname><given-names>Артур Владимирович</given-names></name><name xml:lang="zh"><surname>Kulaev</surname><given-names>Artur V.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><bio xml:lang="zh"><p>MD, Cand. Sci. (Medicine)</p></bio><email>arturkulaev@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8579-2227</contrib-id><contrib-id contrib-id-type="spin">4637-6392</contrib-id><name-alternatives><name xml:lang="en"><surname>Sharkov</surname><given-names>Sergey M.</given-names></name><name xml:lang="ru"><surname>Шарков</surname><given-names>Сергей Михайлович</given-names></name><name xml:lang="zh"><surname>Sharkov</surname><given-names>Sergey M.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><bio xml:lang="zh"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><email>sharkdoc@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6300-1102</contrib-id><contrib-id contrib-id-type="spin">7627-5889</contrib-id><name-alternatives><name xml:lang="en"><surname>Morozov</surname><given-names>Kirill D.</given-names></name><name xml:lang="ru"><surname>Морозов</surname><given-names>Кирилл Дмитриевич</given-names></name><name xml:lang="zh"><surname>Morozov</surname><given-names>Kirill D.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>dr.kirillmorozov@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9758-4441</contrib-id><contrib-id contrib-id-type="spin">8779-2685</contrib-id><name-alternatives><name xml:lang="en"><surname>Kovachich</surname><given-names>Anton S.</given-names></name><name xml:lang="ru"><surname>Ковачич</surname><given-names>Антон Сергеевич</given-names></name><name xml:lang="zh"><surname>Kovachich</surname><given-names>Anton S.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>dr.kov@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8337-3774</contrib-id><contrib-id contrib-id-type="spin">5788-6720</contrib-id><name-alternatives><name xml:lang="en"><surname>Lobach</surname><given-names>Aleksey Yu.</given-names></name><name xml:lang="ru"><surname>Лобач</surname><given-names>Алексей Юрьевич</given-names></name><name xml:lang="zh"><surname>Lobach</surname><given-names>Aleksey Yu.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>uro@alobach.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-7186-2241</contrib-id><contrib-id contrib-id-type="spin">9508-5500</contrib-id><name-alternatives><name xml:lang="en"><surname>Margieva</surname><given-names>Diana A.</given-names></name><name xml:lang="ru"><surname>Маргиева</surname><given-names>Диана Анатольевна</given-names></name><name xml:lang="zh"><surname>Margieva</surname><given-names>Diana A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>dimarodnik93@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Morozovskaya Children’s City Clinical Hospital</institution></aff><aff><institution xml:lang="ru">Морозовская детская городская клиническая больница</institution></aff><aff><institution xml:lang="zh">Morozovskaya Children’s City Clinical Hospital</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Peoples’ Friendship University of Russia</institution></aff><aff><institution xml:lang="ru">Российский университет дружбы народов им. Патриса Лумумбы</institution></aff><aff><institution xml:lang="zh">Peoples’ Friendship University of Russia</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">The First Sechenov Moscow State Medical University</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет им. И.М. Сеченова</institution></aff><aff><institution xml:lang="zh">The First Sechenov Moscow State Medical University</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-10-16" publication-format="electronic"><day>16</day><month>10</month><year>2025</year></pub-date><volume>15</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>307</fpage><lpage>316</lpage><history><date date-type="received" iso-8601-date="2025-04-28"><day>28</day><month>04</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-08-31"><day>31</day><month>08</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><copyright-holder xml:lang="zh">Eco-Vector</copyright-holder><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://rps-journal.ru/jour/article/view/1926">https://rps-journal.ru/jour/article/view/1926</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND:</bold> Extracorporeal shock wave lithotripsy remains the first-line therapy in children with renal stones up to 2 cm. Recently, retrograde intrarenal surgery has become an alternative technology for fragmenting stones located in the renal pelvis and calyces.</p> <p><bold>AIM:</bold> The work aimed to perform a retrospective analysis of the outcomes and complications of flexible ureterorenoscopy in children with urolithiasis.</p> <p><bold>METHODS:</bold> The study included 63 children (65 renal units) who underwent retrograde intrarenal surgery. A total of 70 procedures were performed, including nephrolithotripsy in 59 cases (84.3%) and flexible ureterolithotripsy in 4 cases (5.7%). Nephrolithoextraction and ureterolithoextraction with a flexible endoscope were also performed. Stone size, volume, and density were assessed. The statistical association between the stone-free rate after retrograde intrarenal surgery and other parameters was analyzed using the Mann–Whitney test, Spearman correlation, and logistic regression.</p> <p><bold>RESULTS:</bold><bold> </bold>The median age of the patients was 11.8 years. Computed tomography revealed a median stone size of 13.2 mm and density of 1481 HU. After primary retrograde intrarenal surgery, complete stone clearance was achieved in 49 children (77.81%); after repeat intervention for residual fragments, the overall stone-free rate reached 93.66% (59 patients). Only 2 patients (3.17%) developed ureteral colic due to residual ureteral fragments after stent removal, requiring urgent intervention. Statistically significant predictors of residual fragments included initial stone size &gt;1.6 cm on computed tomography and simultaneous stone location in both the pelvis and calyx (p &lt; 0.05). No association was found between stone-free rate and patient age.</p> <p><bold>CONCLUSION:</bold><bold><italic> </italic></bold>The method of retrograde intrarenal surgery in children demonstrated a high stone-free rate and a low incidence of significant complications.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Актуальность.</bold><bold> </bold>До настоящего времени дистанционная литотрипсия остается первой линией терапии у детей с почечными конкрементами до 2 см. В последнее время альтернативной технологией, позволяющей выполнять дробление камней лоханки и чашечек, стала ретроградная интраренальная хирургия.</p> <p><bold>Цель исследования.</bold><bold> </bold>Провести ретроспективный анализ результатов и осложнений применения гибкого уретерореноскопа у детей с уролитиазом.</p> <p><bold>Методы.</bold><bold> </bold>В исследование включены данные 63 детей (65 почечных единиц), которым выполнена ретроградная интраренальная хирургия: всего 70 процедур ретроградной интраренальной хирургии, из них нефролитотрипсия — в 59 (84,3%) случаях, а гибкая уретеролитотрипсия — в 4 (5,7%). Были проведены также процедуры нефролитоэкстракции и уретеролитоэкстракции с помощью гибкого эндоскопа. Оценивали характеристики размера, объема и плотности камня. Статистическая связь между коэффициентом очищения от камня после процедуры ретроградной интраренальной хирургии и другими данными, была изучена непараметрическими методами Манна–Уитни, Спирмена и логистической регрессии.</p> <p><bold>Результаты.</bold> Медиана возраста пациентов составила 11,8 года. По данным компьютерной томографии медиана размера камня была 13,2 мм, а плотность — 1481 HU. Первичная ретроградная интраренальная хирургия показала полное очищение от камня у 49 (77,81%) детей, а после повторного вмешательства по поводу резидуальных конкрементов коэффициент очищения от камня составил 93,66% (59 пациентов) соответственно. Только у 2 (3,17%) пациентов резидуальные конкременты мочеточника вызвали почечную колику после удаления дренажей и потребовали срочного вмешательства. Статистически значимыми факторами образования резидуальных фрагментов стали исходный размер конкремента по данным компьютерной томографии более 1,6 см и расположение камня в лоханке и чашечке одновременно, <italic>p</italic> &lt;0,05. Связи между коэффициентом очищения от камня и возрастом пациента не установлено.</p> <p><bold>Заключение.</bold><bold> </bold>Метод ретроградной интраренальной хирургии у детей показал высокий коэффициент очищения от камней, а также низкий уровень значимых осложнений.</p></trans-abstract><trans-abstract xml:lang="zh"><p>论证。迄今为止，体外冲击波碎石术仍是儿童直径不超过2 cm的肾结石的一线首选治疗方法。近年来，逆行肾内手术逐渐成为一种替代技术，可用于碎解肾盂及肾盏结石。</p> <p>目的。对儿童泌尿系结石采用柔性输尿管肾镜治疗的结果及并发症进行回顾性分析。</p> <p>方法。共纳入63例患儿（65个肾单位），均接受逆行肾内手术。共实施70例手术，其中肾碎石术59例（84.3%），输尿管碎石术4例（5.7%）。此外，还行柔性内镜下肾结石取石术及输尿管结石取石术。评估结石的大小、体积及密度。结石清除率与其他指标之间的统计学关联采用Mann–Whitney检验、Spearman秩相关分析及逻辑回归方法进行研究。</p> <p>结果。患儿中位年龄为11.8岁。计算机断层扫描显示结石中位直径13.2 mm，中位密度1481 HU。初次逆行肾内手术在49例患儿中实现结石完全清除（77.81%），经再次手术处理残余结石后，总清除率为59例（93.66%）。仅2例（3.17%）患儿因残余输尿管结石在拔除引流管后发生肾绞痛，需紧急干预。 统计分析显示，根据计算机断层扫描结果，结石初始直径&gt;1.6 cm以及结石同时位于肾盂和肾盏， 是残余结石形成的显著危险因素（p&lt;0.05）。患者年龄与结石清除率无相关性。</p> <p>结论。逆行肾内手术方法在儿童泌尿系结石治疗中显示出较高的结石清除率以及较低的严重并发症发生率。</p></trans-abstract><kwd-group xml:lang="en"><kwd>retrograde intrarenal surgery</kwd><kwd>urolithiasis</kwd><kwd>laser lithotripsy</kwd><kwd>flexible ureterorenoscopy</kwd><kwd>children</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>ретроградная интраренальная хирургия</kwd><kwd>мочекаменная болезнь</kwd><kwd>контактная лазерная литотрипсия</kwd><kwd>гибкий уретерореноскоп</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>逆行肾内手术</kwd><kwd>尿路结石病</kwd><kwd>接触性激光碎石术</kwd><kwd>柔性输尿管肾镜</kwd><kwd>儿童</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>European Association of Urology. 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