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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский вестник детской хирургии, анестезиологии и реаниматологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2219-4061</issn><issn publication-format="electronic">2587-6554</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1503</article-id><article-id pub-id-type="doi">10.17816/psaic1503</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Use of ICG navigation in organ-preserving resections of ovarian teratomas in children</article-title><trans-title-group xml:lang="ru"><trans-title>Использование ICG-навигации при органосохраняющих резекциях тератом яичников у детей</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title>ICG导航在儿童卵巢畸胎瘤保留器官切除术中的应用</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2313-897X</contrib-id><contrib-id contrib-id-type="spin">3682-0832</contrib-id><name-alternatives><name xml:lang="en"><surname>Kozlov</surname><given-names>Yury A.</given-names></name><name xml:lang="ru"><surname>Козлов</surname><given-names>Юрий Андреевич</given-names></name><name xml:lang="zh"><surname>Kozlov</surname><given-names>Yury A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), corresponding member of Russian Academy of Sciences; сhief; head of the Department of pediatrics and pediatric surgery; professor of the Department of pediatric surgery</p></bio><bio xml:lang="ru"><p>д-р мед. наук, чл.-корр. РАН; главный врач ИГОДКБ; заведующий кафедрой педиатрии и детской хирургии ИГМУ; профессор кафедры ИГМАПО</p></bio><email>yuriherz@hotmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7042-6646</contrib-id><name-alternatives><name xml:lang="en"><surname>Poloyan</surname><given-names>Simon S.</given-names></name><name xml:lang="ru"><surname>Полоян</surname><given-names>Симон Степанович</given-names></name><name xml:lang="zh"><surname>Poloyan</surname><given-names>Simon S.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>head of pediatric surgery</p></bio><bio xml:lang="ru"><p>заместитель главного врача по хирургической помощи</p></bio><email>simonpoloyan@ya.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9767-0454</contrib-id><name-alternatives><name xml:lang="en"><surname>Marchuk</surname><given-names>Andrei A.</given-names></name><name xml:lang="ru"><surname>Марчук</surname><given-names>Андрей Алексеевич</given-names></name><name xml:lang="zh"><surname>Marchuk</surname><given-names>Andrei A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>surgeon</p></bio><bio xml:lang="ru"><p>детский врач-хирург</p></bio><email>maa-ped20@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7922-7600</contrib-id><contrib-id contrib-id-type="spin">4012-7120</contrib-id><name-alternatives><name xml:lang="en"><surname>Rozhanskii</surname><given-names>Alexander P.</given-names></name><name xml:lang="ru"><surname>Рожанский</surname><given-names>Александр Павлович</given-names></name><name xml:lang="zh"><surname>Rozhanskii</surname><given-names>Alexander P.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>surgical resident</p></bio><bio xml:lang="ru"><p>хирургический ординатор</p></bio><email>alexanderozhanski@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9195-5480</contrib-id><name-alternatives><name xml:lang="en"><surname>Byrgazov</surname><given-names>Anton A.</given-names></name><name xml:lang="ru"><surname>Быргазов</surname><given-names>Антон Алексеевич</given-names></name><name xml:lang="zh"><surname>Byrgazov</surname><given-names>Anton A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>radiologist</p></bio><bio xml:lang="ru"><p>врач-радиолог</p></bio><email>byrgazov.ant-doc38@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4731-7526</contrib-id><name-alternatives><name xml:lang="en"><surname>Muravev</surname><given-names>Sergey A.</given-names></name><name xml:lang="ru"><surname>Муравьев</surname><given-names>Сергей Александрович</given-names></name><name xml:lang="zh"><surname>Muravev</surname><given-names>Sergey A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>6<sup>th</sup> year student</p></bio><bio xml:lang="ru"><p>студент 6-го курса</p></bio><email>muravev1999sergey@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6126-4198</contrib-id><contrib-id contrib-id-type="spin">3965-6284</contrib-id><name-alternatives><name xml:lang="en"><surname>Kovalkov</surname><given-names>Konstantin A.</given-names></name><name xml:lang="ru"><surname>Ковальков</surname><given-names>Константин Анатольевич</given-names></name><name xml:lang="zh"><surname>Kovalkov</surname><given-names>Konstantin A.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.); assistant professor; head of pediatric surgery</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент кафедры детских хирургических болезней; заместитель главного врача по хирургической помощи</p></bio><email>gs-det-hirurg@kuzdrav.ru</email><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff5"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0076-5778</contrib-id><name-alternatives><name xml:lang="en"><surname>Kapuller</surname><given-names>Vadim M.</given-names></name><name xml:lang="ru"><surname>Капуллер</surname><given-names>Вадим Михайлович</given-names></name><name xml:lang="zh"><surname>Kapuller</surname><given-names>Vadim M.</given-names></name></name-alternatives><address><country country="IL">Israel</country></address><bio xml:lang="en"><p>MD, head of Department of Pediatric Surgery</p></bio><bio xml:lang="ru"><p>заведующий отделением детской хирургии</p></bio><email>kapuller@gmail.com</email><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1489-5058</contrib-id><contrib-id contrib-id-type="spin">9030-1493</contrib-id><name-alternatives><name xml:lang="en"><surname>Narkevich</surname><given-names>Artem N.</given-names></name><name xml:lang="ru"><surname>Наркевич</surname><given-names>Артем Николаевич</given-names></name><name xml:lang="zh"><surname>Narkevich</surname><given-names>Artem N.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), assistant professor, head of the Department of medical cybernetics and informatics, dean of the faculty of medicine, head of the laboratory of medical cybernetics and management in health care</p></bio><bio xml:lang="ru"><p>д-р мед. наук, доцент, заведующий кафедрой медицинской кибернетики и информатики; декан лечебного факультета; заведующий лабораторией медицинской кибернетики и управления в здравоохранении</p></bio><email>narkevichart@gmail.com</email><xref ref-type="aff" rid="aff7"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Children’s Regional Clinical Hospital</institution></aff><aff><institution xml:lang="ru">Детская областная клиническая больница</institution></aff><aff><institution xml:lang="zh">Children’s Regional Clinical Hospital</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Irkutsk State Medical Academy of Postgraduate Education</institution></aff><aff><institution xml:lang="ru">Иркутская государственная медицинская академия последипломного образования</institution></aff><aff><institution xml:lang="zh">Irkutsk State Medical Academy of Postgraduate Education</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Irkutsk State Medical University</institution></aff><aff><institution xml:lang="ru">Иркутский государственный медицинский университет</institution></aff><aff><institution xml:lang="zh">Irkutsk State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Yu.A. Atamanov Kuzbass Regional Children’s Hospital</institution></aff><aff><institution xml:lang="ru">Кузбасская областная детская клиническая больница им. Ю.А. Атаманова</institution></aff><aff><institution xml:lang="zh">Yu.A. Atamanov Kuzbass Regional Children’s Hospital</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Kemerovo State Medical University</institution></aff><aff><institution xml:lang="ru">Кемеровский государственный медицинский университет</institution></aff><aff><institution xml:lang="zh">Kemerovo State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="en">Assuta University Medical Center, Ben-Gurion University of the Negev</institution></aff><aff><institution xml:lang="ru">Университетский Медицинский Центр Ассута, Университет им. Бен-Гуриона в Негеве</institution></aff><aff><institution xml:lang="zh">Assuta University Medical Center, Ben-Gurion University of the Negev</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="en">V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University</institution></aff><aff><institution xml:lang="ru">Красноярский государственный медицинский университет им. проф. В.Ф. Войно-Ясенецкого</institution></aff><aff><institution xml:lang="zh">V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-05-23" publication-format="electronic"><day>23</day><month>05</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2023</year></pub-date><volume>13</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>237</fpage><lpage>246</lpage><history><date date-type="received" iso-8601-date="2023-02-24"><day>24</day><month>02</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-05-23"><day>23</day><month>05</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2023,</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://rps-journal.ru/jour/article/view/1503">https://rps-journal.ru/jour/article/view/1503</self-uri><abstract xml:lang="en"><p>This study presents the first experience of indocyanine green imaging for ovarian tumors in girls to show how the development of new imaging technologies can change the treatment of this pathology.</p> <p>A retrospective analysis was conducted on the case histories of a 12-year-old girl and a 15-year-old girl with ovarian teratomas who were admitted with complaints of discomfort and pain in the lower abdomen. Ultrasound and computed tomography of the abdominal cavity revealed tumors with sizes of 40 × 42 × 38 and 60 × 54 × 38 mm in the right ovary for one girl and in the left ovary for the other girl. No increase in the concentration of tumor markers (alpha-fetoprotein, β-chorionic gonadotropin, and Cancer Antigen 125) was recorded. Operations for the diagnosis of ovarian teratoma were performed laparoscopically using fluoroscopic control. The use of indocyanine green imaging was effective in determining the boundaries of the tumor and healthy ovarian tissues, making it possible to perform organ-sparing surgery. During the surgical intervention, no complications were observed in the form of bleeding from the ovarian parenchyma or damage to neighboring organs. Histological diagnosis established that the neoplasms belong to mature teratomas. The length of hospital stay was three days. Ultrasound examination performed six months after surgery showed no signs of disease recurrence. One of the patients exhibited regeneration of ovarian tissues comparable with the size of the contralateral ovary. In another girl, the affected ovary was about half the size.</p> <p>Thus, organ-preserving surgical treatment for ovarian teratomas in children is the method of choice. A fundamental innovation is the use of indocyanine green fluorescence technology to determine the boundaries of the spread of the tumor in order to resect it within healthy tissues.</p></abstract><trans-abstract xml:lang="ru"><p>В статье продемонстрирован первый опыт применения индоцианина зеленого (Indocyanine green) для визуализации опухолей яичников у девочек, чтобы показать, как развитие новых технологий изображения может изменить лечение этой патологии.</p> <p>В исследовании ретроспективно проанализированы истории болезни двух девочек 12 и 15 лет с тератомами яичников, поступившими с жалобами на дискомфорт и боли в нижних отделах живота. При ультразвуковом исследовании и компьютерной томографии брюшной полости диагностированы опухоли размерами 40 × 42 × 38 и 60 × 54 × 38 мм соответственно у одной девочки в правом яичнике, у другой — в левом. Повышение концентрации онкомаркеров (альфа-фетопротеина, β-хорионического гонадотропина и Cancer Antigen 125) не зарегистрировано. Операции по поводу установленного диагноза тератом яичника были выполнены лапароскопическим способом с использованием флуороскопического контроля. Применение визуализации с индоцианином зеленым было эффективным для определения границ опухоли и здоровой ткани яичника, что позволило выполнить органосохраняющую операцию. В ходе хирургического вмешательства не отмечено осложнений в виде кровотечения из паренхимы яичника или повреждений соседних органов. При гистологическом исследовании установлена принадлежность новообразований к зрелым тератомам. Длительность пребывания пациентов в больнице составила 3 дня. При ультразвуковом исследовании через 6 мес. после операции не обнаружено признаков рецидива заболевания. Регенерация ткани яичника, сравнимая с контрлатеральным яичником по размерам, наблюдалась у одной пациентки. У другой девочки пораженный яичник был меньше в размерах приблизительно в два раза.</p> <p>Таким образом, органосохраняющее хирургическое лечение при тератомах яичников у детей можно считать методом выбора. Принципиальной инновацией является использование технологии флуоресценции с индоцианином зеленым для определения границ распространения опухоли с целью ее резекции в пределах здоровых тканей.</p></trans-abstract><trans-abstract xml:lang="zh"><p>这篇文章展示了首次使用吲哚菁绿（Indocyanine green）来观察女孩卵巢肿瘤的经验。这表明， 新成像技术的发展会改变这种病理的治疗。</p> <p>我们在该研究中对两名年龄分别为12岁和15岁的患有卵巢畸胎瘤女孩的病史进行了回顾性分析。这两名女孩因下腹不舒服和疼痛而就医。腹部超声检查和计算机断层扫描诊断出肿瘤，其大小分别为40×42×38和60×54×38毫米。一个女孩的肿瘤在她的右卵巢，另一个在她的左卵巢。癌症标志 物（甲胎蛋白、β-人绒毛膜促性腺激素和癌抗原125）浓度没有升高。诊断为卵巢畸胎瘤的手术是在腹腔镜下进行的，并有透视控制。吲哚菁绿成像技术的使用有效地确定了肿瘤和健康卵巢组织的边界。这使得保留器官手术得以进行。在手术过程中，没有出现卵巢实质出血或邻近器官损伤的并发症。通过组织学检查，这些肿瘤被确定为成熟性畸胎瘤。住院时间为3天。术后6个月的超声检查时没有发现疾病复发的症状。观察到一名患者的卵巢组织再生，其大小与对侧卵巢相当。对于另一个女孩来说，受影响的卵巢大约只有对侧卵巢的一半大小。</p> <p>因此，对儿童卵巢畸胎瘤进行的保留器官手术治疗可以说是首选方法。一个基本的创新是使用吲哚菁绿荧光技术来确定肿瘤扩散的边界，以便在健康组织内切除肿瘤。</p></trans-abstract><kwd-group xml:lang="en"><kwd>ovarian teratoma</kwd><kwd>laparoscopy</kwd><kwd>ICG navigation</kwd><kwd>cases report</kwd><kwd>children</kwd><kwd>oncology</kwd><kwd>gynecology</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>тератома яичника</kwd><kwd>лапароскопия</kwd><kwd>ICG-навигация</kwd><kwd>клинический случай</kwd><kwd>дети</kwd><kwd>онкология</kwd><kwd>гинекология</kwd></kwd-group><kwd-group xml:lang="zh"><kwd>卵巢畸胎瘤</kwd><kwd>腹腔镜检查</kwd><kwd>ICG导航</kwd><kwd>临床病例</kwd><kwd>儿童</kwd><kwd>肿瘤学</kwd><kwd>妇科</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Szymon O, Bogusz B, Taczanowska-Niemczuk A, et al. 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