<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский вестник детской хирургии, анестезиологии и реаниматологии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2219-4061</issn><issn publication-format="electronic">2587-6554</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1260</article-id><article-id pub-id-type="doi">10.17816/psaic1260</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original Study Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные исследования</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Factors contributing to the late diagnosis of appendicitis in children: the results of a retrospective study</article-title><trans-title-group xml:lang="ru"><trans-title>Факторы, способствующие позднему установлению диагноза аппендицита у детей: результаты ретроспективного исследования</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2971-1928</contrib-id><contrib-id contrib-id-type="spin">4185-7287</contrib-id><name-alternatives><name xml:lang="en"><surname>Yanitskaya</surname><given-names>Maria Yu.</given-names></name><name xml:lang="ru"><surname>Яницкая</surname><given-names>Мария Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Assistant Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, доцент</p></bio><email>medmaria@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3130-2920</contrib-id><contrib-id contrib-id-type="spin">2167-7550</contrib-id><name-alternatives><name xml:lang="en"><surname>Kharkova</surname><given-names>Olga A.</given-names></name><name xml:lang="ru"><surname>Харькова</surname><given-names>Ольга Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Psycholog.)</p></bio><bio xml:lang="ru"><p>канд. психол. наук</p></bio><email>harkovaolga@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8807-2062</contrib-id><contrib-id contrib-id-type="spin">5411-6249</contrib-id><name-alternatives><name xml:lang="en"><surname>Markov</surname><given-names>Nikolay V.</given-names></name><name xml:lang="ru"><surname>Марков</surname><given-names>Николай Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><email>nikolarx@gmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9470-8242</contrib-id><contrib-id contrib-id-type="spin">4711-5429</contrib-id><name-alternatives><name xml:lang="en"><surname>Zolotarev</surname><given-names>Nikolay V.</given-names></name><name xml:lang="ru"><surname>Золотарев</surname><given-names>Николай Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Pediatric Surgeon</p></bio><bio xml:lang="ru"><p>детский хирург</p></bio><email>crazymaximus@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Northern State Medical University</institution></aff><aff><institution xml:lang="ru">Северный государственный медицинский университет</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Arkhangelsk Regional Сhildren Clinical Hospital</institution></aff><aff><institution xml:lang="ru">Архангельская областная детская клиническая больница им. П.Г. Выжлецова</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2022-12-23" publication-format="electronic"><day>23</day><month>12</month><year>2022</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-01-19" publication-format="electronic"><day>19</day><month>01</month><year>2023</year></pub-date><volume>12</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>429</fpage><lpage>440</lpage><history><date date-type="received" iso-8601-date="2022-06-05"><day>05</day><month>06</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-12-13"><day>13</day><month>12</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Эко-Вектор</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://rps-journal.ru/jour/article/view/1260">https://rps-journal.ru/jour/article/view/1260</self-uri><abstract xml:lang="en"><p><bold><italic>BACKGROUND</italic></bold><italic>:</italic> The diagnosis of acute appendicitis in children is often established late, which leads to complications, lethal outcomes are recorded.</p> <p><bold><italic>AIM</italic></bold><italic>: </italic>To identify and analyze the factors contributing to the late diagnosis of acute appendicitis in children.</p> <p><bold><italic>MATERIALS AND</italic></bold> <bold><italic>METHODS</italic></bold><italic>:</italic> A retrospective analysis of 279 case histories of children was carried out. The duration of symptoms is divided into “time 1” (before hospitalization) and “time 2” (from hospitalization to surgery). Patients were divided into two groups: 1<sup>st</sup> — with destructive uncomplicated appendicitis (phlegmonous, gangrenous), 2<sup>nd</sup> — with complicated appendicitis (unrestricted peritonitis, infiltrate, abscess). The causes of late hospitalization, symptoms indicated in the case histories, examinations performed, postoperative complications were analyzed. The diagnosis was established on the basis of intraoperative data, histological examination.</p> <p><bold><italic>RESULTS</italic></bold><italic>:</italic> In the 1<sup>st</sup> group, time 1 and time 2 were significantly less than in the 2<sup>nd</sup> (<italic>p</italic> &lt; 0.001; 0.028). Late presentation (&gt;24 hours) in 21.9%, misdiagnosis in 12.2% of cases. In the hospital, the observation of the patient &gt;12 hours in 21.1% of patients. The frequency of presence / absence of a description of clinical and laboratory signs of acute appendicitis is from 100 to 19.7%. The 2<sup>nd</sup> group was characterized by: duration of symptoms &gt;24 hours, repeated vomiting (<italic>p</italic> &lt; 0.001), febrile condition (<italic>p</italic> &lt; 0.001), increase in neutrophils 90% (87–92%). Ultrasound examination with evaluation of the appendix — in 20.1% of cases with a diagnostic accuracy of 89.3%. Laparoscopic appendectomy in 53.2% Alvarado scores are significantly higher in 2<sup>nd</sup> group (8–10) than in 1<sup>st</sup> group (7–9, <italic>p</italic> &lt; 0.001). In 1<sup>st</sup> group, complications were significantly less than 3.4% than in 2<sup>nd</sup> group — 22.7 % (<italic>p</italic> &lt; 0.001).</p> <p><bold><italic>CONCLUSIONS</italic></bold><italic>:</italic> Factors contributing to the late diagnosis of appendicitis in children are: late treatment, diagnostic errors at the prehospital stage, incomplete clinical examination and observation, insufficient use of laboratory and instrumental methods.</p></abstract><trans-abstract xml:lang="ru"><p><bold><italic>Актуальность</italic></bold><italic>.</italic> Диагноз острого аппендицита у детей нередко устанавливается поздно, что приводит к осложнениям, фиксируются летальные исходы.</p> <p><bold><italic>Цель</italic></bold> — выявить и проанализировать факторы, способствующие позднему установлению диагноза острого аппендицита у детей.</p> <p><bold><italic>Материалы и методы</italic></bold><italic>.</italic> Проведен ретроспективный анализ 279 историй болезни детей. Длительность симптомов разделена на «время 1» (до госпитализации) и «время 2» (от госпитализации до операции). Пациенты разделены на две группы: 1-я — с деструктивным неосложненным аппендицитом (флегмонозным, гангренозным); 2-я — с осложненным аппендицитом (перитонит неограниченный, инфильтрат, абсцесс). Анализировали причины поздней госпитализации, симптомы, указанные в историях болезни, выполненные обследования, послеоперационные осложнения. Диагноз устанавливался на основании интраоперационных данных, гистологического исследования.</p> <p><bold><italic>Результаты</italic></bold><italic>.</italic> В 1-й группе время 1 и время 2 достоверно меньше, чем во 2-й (<italic>р</italic> &lt; 0,001; 0,028). Позднее обращение (&gt;24 ч) — в 21,9 %, ошибочный диагноз — в 12,2 % случаев. В стационаре наблюдение пациента &gt;12 ч — у 21,1 % пациентов. Частота наличия/отсутствия описания клинических и лабораторных признаков острого аппендицита — от 100 до 19,7 %. Для 2-й группы были характерны: давность симптомов &gt;24 ч, многократная рвота (<italic>р</italic> &lt; 0,001), фебрилитет (<italic>р</italic> &lt; 0,001), повышение нейтрофилов 90 (87–92) %. Ультразвуковое исследование с оценкой аппендикса проведено в 20,1 % наблюдений с диагностической точностью 89,3 %, лапароскопическая аппендэктомия — в 53,2 %. Баллы по шкале Альварадо значимо выше во 2-ой группе (8–10), чем в 1-й (7–9, <italic>р</italic> &lt; 0,001). В 1-й группе осложнений было достоверно меньше (3,4 %), чем во 2-й группе — 22,7 % (<italic>р</italic> <italic>&lt;</italic> 0,001).</p> <p><bold><italic>Заключение</italic></bold><italic>.</italic> Факторами, способствующими позднему установлению диагноза аппендицита у детей, можно считать позднее обращение, диагностические ошибки на догоспитальном этапе, неполное клиническое обследование и наблюдение, недостаточное использованием лабораторных и инструментальных методов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>appendicitis</kwd><kwd>children</kwd><kwd>diagnostics</kwd><kwd>Alvarado scale</kwd><kwd>laparoscopy</kwd><kwd>ultrasound</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аппендицит</kwd><kwd>дети</kwd><kwd>диагностика</kwd><kwd>шкала Альварадо</kwd><kwd>лапароскопия</kwd><kwd>ультразвуковое исследование</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Detskaya khirurgiya: natsional’noe rukovodstvo dlya vrachei. Razumovsky AY, ed. Moscow, Medicina: GEOTAR-Media; 2021. 1280 p. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Детская хирургия: национальное руководство для врачей / под ред. А.Ю. Разумовского. Москва: ГЭОТАР-Медиа, 2021. 1280 с.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Razumovsky AY, Dronov AF, Smirnov AN, Golovanev МА. Acute appendicitis in children. Clinical guidelines. Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care. 2013; 3(4):125–131. (In Russ.)</mixed-citation><mixed-citation xml:lang="ru">Разумовский А.Ю., Дронов А.Ф., Смирнов А.Н., Голованев М.А. Острый аппендицит у детей. Клинические рекомендации // Российский вестник детской хирургии, анестезиологии и реаниматологии. 2013. Т. 3, № 4. С. 125–131.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">Revishvili Ash, Olovyanny VE, Kalinin DV, Kuznetsov AV. Mortality in acute appendicitis in Russia. Pirogov Journal of Surgery. 2022;10:5–14. (In Russ.) DOI: 10.17116/hirurgia20221015</mixed-citation><mixed-citation xml:lang="ru">Ревишвили А.Ш., Оловянный В.Е., Калинин Д.В., Кузнецов А.В. Летальность при остром аппендиците в России // Хирургия. Журнал имени Н.И. Пирогова. 2022. № 10. С. 5–14. DOI: 10.17116/hirurgia20221015</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">Birnbaum BA, Wilson SR. Appendicitis at the millennium. Radiology. 2000;215(2):337–348. DOI: 10.1148/radiology.215.2.r00ma24337</mixed-citation><mixed-citation xml:lang="ru">Birnbaum B.A., Wilson S.R. Appendicitis at the millennium // Radiology 2000. Vol. 215, No. 2. P. 337–348. DOI: 10.1148/radiology.215.2.r00ma24337</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">Canal C, Lempert M, Birrer D, et al. Short-term outcome after appendectomy is related to preoperative delay but not to the time of day of the procedure: A nationwide retrospective cohort study of 9224 patients. Int J Surg. 2020;76:16–24. DOI: 10.1016/j.ijsu.2020.02.001</mixed-citation><mixed-citation xml:lang="ru">Canal C., Lempert M., Birrer D., et al. Short-term outcome after appendectomy is related to preoperative delay but not to the time of day of the procedure: A nationwide retrospective cohort study of 9224 patients // Int J Surg. 2020. Vol. 76. P. 16–24. DOI: 10.1016/j.ijsu.2020.02.001</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">Peyvasteh M, Askarpour S, Javaherizadeh H, Besharati S. Modified Alvarado score in children with diagnosis of appendicitis. Arq Bras Cir Dig. 2017;30(1):51–52. DOI: 10.1590/0102-6720201700010014.</mixed-citation><mixed-citation xml:lang="ru">Peyvasteh M., Askarpour S., Javaherizadeh H., Besharati S. Modified Alvarado score in children with diagnosis of appendicitis // Arq Bras Cir Dig. 2017. Vol. 30, No. 1. P. 51–52. DOI: 10.1590/0102-6720201700010014</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">Samuel M. Pediatric appendicitis score. J Pediatr Surg. 2002;37(6):877–881. DOI: 10.1053/jpsu.2002.32893.</mixed-citation><mixed-citation xml:lang="ru">Samuel M. Pediatric appendicitis score // J Pediatr Surg. 2002. Vol. 37, No. 6. P. 877–881. DOI: 10.1053/jpsu.2002.32893</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">Alvarado A. A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med. 1986;15(5):557–564. DOI: 10.1016/s0196-0644(86)80993-3</mixed-citation><mixed-citation xml:lang="ru">Alvarado A. A practical score for the early diagnosis of acute appendicitis // Ann Emerg Med. 1986. Vol. 15, No. 5. P. 557–564. DOI: 10.1016/s0196-0644(86)80993-3</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">Noor S, Wahab A, Afridi G, Ullah K. Comparing Ripasa Score and Alvarado Score in an accurate diagnosis of acute appendicitis. J Ayub Med Coll Abbottabad. 2020;32(1):38–41.</mixed-citation><mixed-citation xml:lang="ru">Noor S., Wahab A., Afridi G., Ullah K. Comparing ripasa score and alvarado score in an accurate diagnosis of acute appendicitis // J Ayub Med Coll Abbottabad. 2020. Vol. 32, No. 1. P. 38–41.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">Benabbas R, Hanna M, Shah J, Sinert R. Diagnostic accuracy of history, physical examination, laboratory tests, and point-of-care ultrasound for pediatric acute appendicitis in the emergency department: a systematic review and meta-analysis. Review Acad Emerg Med. 2017;24(5):523–551. DOI: 10.1111/acem.13181</mixed-citation><mixed-citation xml:lang="ru">Benabbas R., Hanna M., Shah J., Sinert R. Diagnostic accuracy of history, physical examination, laboratory tests, and point-of-care ultrasound for pediatric acute appendicitis in the emergency department: a systematic review and meta-analysis // Review Acad Emerg Med. 2017. Vol. 24, No. 5. P. 523–551. DOI: 10.1111/acem.13181</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">Bhangu A, Søreide K, Di Saverio S, Assarsson J, Drake F. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet. 2015;386(10000):1278–1287. DOI: 10.1016/S0140-6736 (15)00275-5</mixed-citation><mixed-citation xml:lang="ru">Bhangu A., Søreide K., Di Saverio S., et al. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management // Lancet. 2015. Vol. 386, No. 10000. P. 1278–1287. DOI: 10.1016/S0140-6736 (15)00275-5</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">Samusenko AA, Rayanov NV. Diagnostic errors in the diagnosis of acute apepiditis in young children. HERALD of North-Western State Medical University named after I.I. Mechnikov. 2018;10(1):86–88. (In Russ.) DOI: 10.17816/mechnikov201810186-88.</mixed-citation><mixed-citation xml:lang="ru">Самусенко А.А., Раянов Н.В. Диагностические ошибки в диагностике острого аппендицита у детей раннего возраста // Вестник Северо-Западного государственного медицинского университета им. И.И. Мечникова. 2018. Т. 10, № 1. C. 86–88. DOI: 10.17816/mechnikov201810186-88</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">Almaramhy HH. Acute appendicitis in young children less than 5 years: review article. Ital J Pediatr. 2017;43(1):15. DOI: 10.1186/s13052-017-0335-2.</mixed-citation><mixed-citation xml:lang="ru">Almaramhy H.H. Acute appendicitis in young children less than 5 years: review article // Ital J Pediatr. 2017. Vol. 43, No. 1. P. 15. DOI: 10.1186/s13052-017-0335-2</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">Awayshih MMA, Yousef AJ, Nofal MN. Evaluation of Alvarado score in diagnosing acute appendicitisю. J Univer Surg. 2019;34:15. DOI: 10.11604/pamj.2019.34.15.17803</mixed-citation><mixed-citation xml:lang="ru">Awayshih M.M.A., Yousef A.J., Nofal M.N. Evaluation of Alvarado score in diagnosing acute appendicitis. // J Univer Surg. 2019. Vol. 34. P. 15. DOI: 10.11604/pamj.2019.34.15.17803</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Abou Merhi B, Khalil M, Daoud N. Comparison of Alvarado score evaluation and clinical judgment in acute appendicitis. Med Arch. 2014;68(1):10–13. DOI: 10.5455/medarh.2014.68.10-13</mixed-citation><mixed-citation xml:lang="ru">Abou Merhi B., Khalil M., Daoud N. Comparison of Alvarado score evaluation and clinical judgment in acute appendicitis // Med Arch. 2014. Vol. 68, No.1. P. 10–13. DOI: 10.5455/medarh.2014.68.10-13</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">Mary EK, Abdulhameed A, Ankit B, et al. The Washington Manual of Surgery. 6th ed. Philadelphia: Lippincott Williams &amp; Wilkins; 2011. P. 930.</mixed-citation><mixed-citation xml:lang="ru">Mary E.K., Abdulhameed A., Ankit B., et al. The Washington Manual of Surgery. 6th ed. Philadelphia: Lippincott Williams &amp; Wilkins, 2011. P. 930.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">Brewster GS, Herbert ME. Medical myth: a digital rectal examination should be performed on all individuals with possible appendicitis. West J Med. 2000;173(3):207–208. DOI: 10.1136/ewjm.173.3.207</mixed-citation><mixed-citation xml:lang="ru">Brewster G.S., Herbert M.E. Medical myth: a digital rectal examination should be performed on all individuals with possible appendicitis // West J Med. 2000. Vol. 173, No. 3. P. 207–208. DOI: 10.1136/ewjm.173.3.207</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">Khoshnood A, Ekelund U. Routine rectal palpation in acute abdomen has no proven value. A review of the literature. Lakartidningen. 2014;111(3-4):89–90.</mixed-citation><mixed-citation xml:lang="ru">Khoshnood A., Ekelund U. Routine rectal palpation in acute abdomen has no proven value. A review of the literature // Lakartidningen. 2014. Vol. 111, No. 3-4. P. 89–90.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">Takada T, Nishiwaki H, Yamamoto Y, et al. The Role of digital rectal examination for diagnosis of acute appendicitis: a systematic review and meta-analysis. PLoS ONE. 2015;10(9):e013699. DOI: 10.1371/journal.pone.0136996</mixed-citation><mixed-citation xml:lang="ru">Takada T., Nishiwaki H., Yamamoto Y., et al. The role of digital rectal examination for diagnosis of acute appendicitis: a systematic review and meta-analysis // PLoS ONE. 2015. Vol. 10, No. 9. P. e013699. DOI: 10.1371/journal.pone.0136996</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">Fu J, Zhou X, Chen L, Lu S. Abdominal ultrasound and its diagnostic accuracy in diagnosing acute appendicitis: a meta-analysis. Front Surg. 2021;8:707160. DOI: 10.3389/fsurg.2021.707160</mixed-citation><mixed-citation xml:lang="ru">Fu J., Zhou X., Chen L., Lu S. Abdominal ultrasound and its diagnostic accuracy in diagnosing acute appendicitis: a meta-analysis // Front Surg. 2021. Vol. 8. P. 707160. DOI: 10.3389/fsurg.2021.707160</mixed-citation></citation-alternatives></ref><ref id="B21"><label>21.</label><citation-alternatives><mixed-citation xml:lang="en">Shirazi AS, Sametzadeh M, Kamankesh R, Rahim F. Accuracy of sonography in diagnosis of acute appendicitis running. Pakistan Journal of Biological Sciences. 2010;13(4):190–193. DOI: 10.3923/pjbs.2010.190.193</mixed-citation><mixed-citation xml:lang="ru">Shirazi A.S., Sametzadeh M., Kamankesh R., Rahim F. Accuracy of sonography in diagnosis of acute appendicitis running // Pakistan Journal of Biological Sciences. 2010. Vol. 13, No. 4. P. 190–193. DOI: 10.3923/pjbs.2010.190.193</mixed-citation></citation-alternatives></ref><ref id="B22"><label>22.</label><citation-alternatives><mixed-citation xml:lang="en">Kabir SA, Kabir SI, Sun R, et al. How to diagnose an acutely inflamed appendix; a systematic review of the latest evidence. Int J Surg. 2017;40:155–162. DOI: 10.1016/j.ijsu.2017.03.013</mixed-citation><mixed-citation xml:lang="ru">Kabir S.A., Kabir S.I., Sun R., et al. How to diagnose an acutely inflamed appendix; a systematic review of the latest evidence // Int J Surg. 2017. Vol. 40. P. 155–162. DOI: 10.1016/j.ijsu.2017.03.013</mixed-citation></citation-alternatives></ref><ref id="B23"><label>23.</label><citation-alternatives><mixed-citation xml:lang="en">Alhamdani YF, Rizk HA, Algethami MR, et al. Negative appendectomy rate and risk factors that influence improper diagnosis at King Abdulaziz University Hospital. Mater Sociomed. 2018;30(3):215–220. DOI: 10.5455/msm.2018.30.215-220</mixed-citation><mixed-citation xml:lang="ru">Alhamdani Y.F., Rizk H.A., Algethami M.R., et al. Negative appendectomy rate and risk factors that influence improper diagnosis at King Abdulaziz University Hospital // Mater Sociomed. 2018. Vol. 30, No. 3. P. 215–220. DOI: 10.5455/msm.2018.30.215-220</mixed-citation></citation-alternatives></ref><ref id="B24"><label>24.</label><citation-alternatives><mixed-citation xml:lang="en">Mariadason JG, Wang WN, Wallack MK, et al. Negative appendicectomy rate as a quality metric in the management of appendicitis: impact of computed tomography, Alvarado score and the definition of negative appendicectomy. Ann R Coll Surg Engl. 2012;94(6):395–401. DOI: 10.1308/003588412X13171221592131</mixed-citation><mixed-citation xml:lang="ru">Mariadason J.G., Wang W.N., Wallack M.K., et al. Negative appendicectomy rate as a quality metric in the management of appendicitis: impact of computed tomography, Alvarado score and the definition of negative appendicectomy // Ann R Coll Surg Engl. 2012. Vol. 94, No. 6. P. 395–401. DOI: 10.1308/003588412X13171221592131</mixed-citation></citation-alternatives></ref></ref-list></back></article>
