MORPHOLOGICAL TRANSFORMATION OF THE INTESTINAL WALL IN NEWBORNS WITH NECROTISING ENTEROCOLITIS

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Abstract

The purpose is to present morphological and morphometric changes in the histoarchitecture of the intestinal wall in newborns with necrotizing enterocolitis considering the outcomes of the disease. Materials and methods. The PRMU clinics carried out a morphological study of histological intestinal sections of 99 operated patients with NEC from 2003 to 2017. The patients were divided into the following groups: 72 survived newborns from group I (favourable outcome) and 27 dead newborns from group II (unfavourable outcome). The object under study was surgical specimen of the ileum and large intestine. Result. The disease outcome can be predicted using morphological changes in the intestinal wall in NEC. The leading role of the drainage function of the lymphatic apparatus is established in the article. It is completely restructured in the operational specimen of patients with the unfavourable course. Changes in the cellular composition in the form of insufficient number of fibroblast cells and isolated epithelial and stromal cells enabled subsequent destruction of the bowel wall with progression of the exudative processes.

About the authors

I. Yu. Karpova

Privolzhsky Research Medical University

Author for correspondence.
Email: ikarpova73@mail.ru

Irina Yu. KARPOVA - Dr. Sci. (Med.), associate professor, professor of the Department of Pediatric Surgery

10/1, pl. Minin and Pozharsky, Nizhny Novgorod, 603005

Russian Federation

V. V. Parshikov

Privolzhsky Research Medical University

Email: fake@neicon.ru

Vyacheslav V. PARSHIKOV - Dr. Sci. (Med.), professor, head of the Department of Pediatric Surgery

10/1, pl. Minin and Pozharsky, Nizhny Novgorod, 603005

Russian Federation

N. Yu. Shirokova

Privolzhsky Research Medical University

Email: fake@neicon.ru

Natalia Yu. SHIROKOVA - Cand. sci. (Biol.), senior researcher, pathological anatomy group

10/1, pl. Minin and Pozharsky, Nizhny Novgorod, 603005

Russian Federation

Е. D. Pyatova

Privolzhsky Research Medical University

Email: fake@neicon.ru

Evgenia D. PYATOVA - Senior lecturer of the Department of Medical Physics and Informatics

10/1, pl. Minin and Pozharsky, Nizhny Novgorod, 603005

Russian Federation

D. V. Molchanova

Children’s City Clinical Hospital № 27

Email: fake@neicon.ru

Daria V. MOLCHANOVA - Doctor – pediatric surgeon

7A, Yaroshenko st., Nizhny Novgorod, 603035

Russian Federation

A. A. Bebenina

Privolzhsky Research Medical University

Email: fake@neicon.ru

Anastasia A. Bebenina  - 6th year student of the Pediatric Faculty

10/1, pl. Minin and Pozharsky, Nizhny Novgorod, 603005

Russian Federation

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Copyright (c) 2018 Karpova I.Y., Parshikov V.V., Shirokova N.Y., Pyatova Е.D., Molchanova D.V., Bebenina A.A.

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