PROPOFOL-INDUCED METABOLIC DISTRESS SYNDROME

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Abstract


Introduction. The obtained experience of using propofol under clinical conditions and in experimental studies discover the mechanism of a negative drug effect at the level of mitochondrial enzymes which is currently treated as the propofol infusion syndrome.

Purpose. To demonstrate the cases of creatine phosphokinase level variation during the intraoperative pediatric use of propofol in anesthesia.

Materials and methods. Three cases of intraoperative use of propofol in 2–17‑years-old patients with different dosages and dose schedules.

Results. The level of creatine phosphokinase was increased 9–44 times within 2–5 days of postoperative period without any significant disturbances or with insignificant changes in the levels of transaminase and lactic dehydrogenase (LDG).

Conclusion. Propofol-based variation in the cellular metabolism proven today rather corresponds to the term ‘propofol-induced metabolic distress syndrome’. It can be manifested both at the level of clinical symptoms and subclinically, without any evident clinical signs with short-term transient variations of laboratory parameters only (acid-base balance (ABB), transaminase, LDG and CPK).


About the authors

V. V. Lazarev

Pirogov Russian National Research Medical University

Author for correspondence.
Email: 1dca@mail.ru

Russian Federation

LAZAREV Vladimir Viktorovich –  M. D., Ph.D., Professor, Chairman of the Department of Pediatric Anesthesiology and Intensive Care

Ostrovityanova str., 1, Moscow, 117997

S. A. Daryin

Russian Children's Clinical Hospital

Email: 1dca@mail.ru

Russian Federation

DARYIN Sergei Andreevich – Reanimatologist of pediatric intensive care unit

Moscow

G. P. Brusov

Russian Children's Clinical Hospital

Email: 1dca@mail.ru

Russian Federation

BRUSOV Gleb Pavlovich – Chairman of pediatric intensive care unit

Moscow

L. E. Tsypin

Pirogov Russian National Research Medical University

Email: 1dca@mail.ru

Russian Federation

TSYPIN Leonid Efimovich – M. D., Ph.D., Professor, Professor of the Department of Pediatric Anesthesiology and Intensive Care

Moscow

T. G. Popova

Pirogov Russian National Research Medical University

Email: 1dca@mail.ru

Russian Federation

POPOVA Tatiana Georgievna – M. D., Ph.D., Associate Professor of the Department of Pediatric Anesthesiology and Intensive Care

Moscow

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