MODERN VIEW ON THE DEVELOPMENT AND TREATMENT OF HYPOSPADIA

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Abstract

Hypospadia is a malformation of the penis when incomplete fusion of ureteral folds and the ectopy of the ureteral outlet are observed; depending on its position according to Barcat there are anterior, medium and posterior forms of hypospadias. The main reasons for hypospadias development are genetic disturbances and hormonal shifts such as a low level of testosterone. Peculiarities of the prepuce skin blood supply in hypospadias are irregular and diffuse type of vascular branching and insufficient prepuce skin vascularization pointing at the conjugation of penis malformation disturbances and dysangiogenesis. The degree of vascularization of prepuce skin derma various in three forms of hypospadia also produces a significant effect on the favourable course of the postoperative period. Both its excessive and weak blood supply can complicate the course of the postoperative period forming ureteral fistulas. An inflammatory component stimulating the pathological angiogenesis is considered as the aggravating factor. Sufficient blood supply of the prepuce skin in the lack of a pronounced inflammatory reaction is an important criterion of favourable outcome of the postoperative period. 

About the authors

L. O. Severgina

I. M. Sechenov First Moscow State University

Author for correspondence.
Email: fake@neicon.ru
Доктор медицинских наук, профессор кафедры патологической анатомии лечебного факультета имени академика А. И. Струкова Russian Federation

L. B. Menovschikova

N. I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia

Email: fake@neicon.ru
Доктор медицинских наук, профессор кафедры детской хирургии Russian Federation

I. A. Korovin

I. M. Sechenov First Moscow State University

Email: fake@neicon.ru
Студент 3‑го курса лечебного факультета Russian Federation

References

  1. Ашкрафт К. У., Холдер Т. М. Детская хирургия. Т. III. Санкт-Петербург, 1999. С. 28–50, 79–105.
  2. Волкова О. В., Пекарский М. И. Эмбриогенез и возрастная гистология внутренних органов человека. Москва, 1976.
  3. Лопаткин Н. А., Пугачев А. Г. Детская урология: Руководство. Москва, 1986. С. 217–242.
  4. Люлько А. В. Хирургическая андрология. Москва, 2005. С. 159–212.
  5. Савченко Н. Е. Гипоспадия и гермафродитизм. Минск, 1974.
  6. Севергина Л. О. Роль дизангиогенеза в пороках развития мочеполовой системы // Автореферат дисс. Москва, 2014.
  7. Ташпулатов Б. К. Оценка гормонального статуса у детей с гипоспадией // Автореферат дисс. Москва, 2009.
  8. Baskin L. S., Himes K., Colborn T. Hypospadias and endocrine disruption: is there a connection? // Environ. Health Perspect., 2011, Nov.109 (11), рр.1175–1183.
  9. Beleza-Meireles A., Lundberg F. FGFR2, FGF10 and BMP7 as candidate genes for hypospadias // Eur J. Genet, 2007, Apr15 (4), P405–410
  10. Duckett J. W. Advances in hypospadias repair // Postgrad. Med. J., 1990, 66 Suppl.1, рр.62–71.
  11. Holmes N. M., Miller W. L., Baskin L. S. Lack of defects in androgen production in children with hypospadias // J. Clin. Endocrinol. Metab, 2004, Jun89 (6), рр.2811–2816.
  12. Leung A. K., Robson W. L. Hypospadias: an update. Asian J. Androl, 2007, Jan. 9 (1), pp.16–22.
  13. Lissbrant I. F., Lissbrant E., Persson A., Damber J. E., Bergh A. Endothelial cell proliferation in male reproductive organs of adult rats is high and regulated by testicular factors // Biol. Reprod. 2003, Apr, 68 (4), рр.1107–1111.
  14. Nordenvall A. S., Paucar M., Almqvist C. Hypospadias as a novel feature of spinal bulbar muscle atrophy // J. Neurol. 2016, Apr. 263 (4), pp.703–6.
  15. Perovic S. V., Radojicic Z. I. Vasculatisation of the hypospadic prepuce and its impact on hypospadic repair // J. Urol. 2003, Mar, 169 (3), pp.1098–1001.
  16. Radojicic Z. I., Perovic S. V. Classification of prepuce in hypospadias according to morphological abnormalities and their impact on hypospodias repair // J. Urol. 2004 Jul, 172 (1), рр.301–304.
  17. Skakkebaek N. E., Rajpert-De Meyts E., Buck Louis G. M. Male Reproductive Disorders and Fertility Trends: Influences of Environmental and Genetic Susceptibility // Physiol. Rev. 2016, Jan, 96 (1), pp.55–97.
  18. Springer A., van den Heijkant M., Baumann S. Worldwide prevalence of hypospadias // J. pediatr. Urology. 2015, Dec, 12, pp.1477–85.
  19. Stern J. M., Chen J., Peters S. B., Stahl P. J., El-Chaar M., Falsen D., Poppas D. P. Testosterone treatment of human foreskin in a novel transplant model // Urology, 2004, May, 63 (5), рр.999–1003.
  20. Yucel S., Guntekin E., Кukul E., Ciftcioglu A., Melocoglu M., Baykara M. Comparison of hypospadic and normal preputial vascular anatomy // J. Urol. 2004 Nov, 172 (5 Pt 1), pp.1973–1976.

Copyright (c) 2016 Severgina L.O., Menovschikova L.B., Korovin I.A.

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