The use of indocyanine green navigation in the treatment of a choledochal cyst in a child
- Authors: Kozlov Y.A.1,2,3, Rozhanski A.P.1,3, Makarochkina M.V.1, Sapukhin E.V.1, Strashinsky A.S.1, Ryakhina A.O.1, Semshchikova Y.P.3
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Affiliations:
- Irkutsk State Regional Children’s Clinical Hospital
- Irkutsk State Medical Academy of Postgraduate Education—a branch of the Russian Medical Academy of Continuous Professional Education
- Irkutsk State Medical University
- Issue: Vol 26, No 1 (2026)
- Pages: 111-118
- Section: Case reports
- Submitted: 02.01.2025
- Accepted: 12.03.2026
- Published: 30.03.2026
- URL: https://rps-journal.ru/jour/article/view/1884
- DOI: https://doi.org/10.17816/psaic1884
- EDN: https://elibrary.ru/EQSGOG
- ID: 1884
Cite item
Abstract
In pediatric surgery, near-infrared fluorescence imaging using indocyanine green has become widespread. This report presents a new approach for intraoperative identification of extrahepatic bile duct anatomy during laparoscopic choledochal cyst resection and hepatoduodenostomy formation in a pediatric patient. A 10-month-old girl presented with episodes of restlessness accompanied by vomiting. On prenatal ultrasound, a cystic lesion was detected in the hepatic portal region, and its presence was subsequently confirmed on postnatal imaging. Contrast-enhanced computed tomography and magnetic resonance cholangiopancreatography revealed a Todani type Ib choledochal cyst measuring 2.2×1.6×1.6 cm. For intraoperative fluorescence navigation, indocyanine green (0.25 mg/kg) was administered intravenously 12 hours before surgery. The procedure consisted of laparoscopic cyst resection followed by hepatoduodenostomy creation. Operative time was 120 minutes. Fluorescence imaging clearly delineated the distal margin of the cyst within the pancreatic parenchyma and its proximal extent at the level of the common hepatic duct. Enteral feeding was initiated on postoperative day 2. No intraoperative complications occurred. Postoperatively, the patient showed improvement, with decreased bilirubin levels and liver enzyme activity. No evidence of anastomotic leakage was found during early follow-up. Hospital stay was 7 days. At 6 months of follow-up, the patient had no clinical or laboratory signs of obstructive jaundice or cholangitis. In conclusion, fluorescence imaging with indocyanine green is a safe and highly informative method for intraoperative identification and resection of a choledochal cyst.
Full Text
About the authors
Yury A. Kozlov
Irkutsk State Regional Children’s Clinical Hospital; Irkutsk State Medical Academy of Postgraduate Education—a branch of the Russian Medical Academy of Continuous Professional Education; Irkutsk State Medical University
Email: yuriherz@hotmail.com
ORCID iD: 0000-0003-2313-897X
SPIN-code: 3682-0832
MD, Dr. Sci. (Medicine), Professor, Corresponding Member of the Russian Academy of Sciences
Russian Federation, Irkutsk; Irkutsk; IrkutskAlexander P. Rozhanski
Irkutsk State Regional Children’s Clinical Hospital; Irkutsk State Medical University
Author for correspondence.
Email: alexanderozhanski@mail.ru
ORCID iD: 0000-0001-7922-7600
SPIN-code: 4012-7120
MD
Russian Federation, Irkutsk; IrkutskMarina V. Makarochkina
Irkutsk State Regional Children’s Clinical Hospital
Email: makarochkina@igodkb.ru
ORCID iD: 0000-0001-8295-6687
SPIN-code: 4600-4071
MD
Russian Federation, IrkutskEduard V. Sapukhin
Irkutsk State Regional Children’s Clinical Hospital
Email: sapukhin@yandex.ru
ORCID iD: 0000-0001-5470-7384
MD
Russian Federation, IrkutskAlexey S. Strashinsky
Irkutsk State Regional Children’s Clinical Hospital
Email: leksus-642@yandex.ru
ORCID iD: 0000-0002-1911-4468
SPIN-code: 9210-5286
MD
Russian Federation, IrkutskAnna O. Ryakhina
Irkutsk State Regional Children’s Clinical Hospital
Email: romahka@yandex.ru
ORCID iD: 0009-0006-0340-1186
MD
Russian Federation, IrkutskYulia P. Semshchikova
Irkutsk State Medical University
Email: jsemshikova@mail.ru
ORCID iD: 0000-0001-9049-0450
MD, Cand. Sci. (Medicine), Assistant Professor
Russian Federation, IrkutskReferences
- Miyano T, Yamataka A, Kato Y, et al. Hepaticoenterostomy after excision of choledochal cyst in children: a 30-year experience with 180 cases. J Pediatr Surg. 1996;31(10):1417–1421. doi: 10.1016/s0022-3468(96)90843-x
- de Vries JS, de Vries S, Aronson DC, et al. Choledochal cysts: age of presentation, symptoms, and late complications related to Todani’s classification. J Pediatr Surg. 2002;37(11):1568–1573. doi: 10.1053/jpsu.2002.36186
- Davenport M, Betalli P, D’Antiga L, et al. The spectrum of surgical jaundice in infancy. J Pediatr Surg. 2003;38(10):1471–1479. doi: 10.1016/s0022-3468(03)00498-6
- Madadi-Sanjani O, Wirth TC, Kuebler JF, et al. Choledochal cyst and malignancy: A plea for lifelong follow-up. Eur J Pediatr Surg. 2019;29(2):143–149. doi: 10.1055/s-0037-1615275
- Stewart HL, Birch DJS. Fluorescence guided surgery. Method Appl Fluoresc. 2021;9(4). doi: 10.1088/2050-6120/ac1dbb
- Paraboschi I, De Coppi P, Stoyanov D, et al. Fluorescence imaging in pediatric surgery: State-of-the-art and future perspectives. J Pediatr Surg. 2021;56(4):655–662. doi: 10.1016/j.jpedsurg.2020.08.004
- Alghoul H, Al Farajat F, Alser O, et al. Intraoperative uses of near-infrared fluorescence spectroscopy in pediatric surgery: A systematic review. J Pediatr Surg. 2022;57(6):1137–1144. doi: 10.1016/j.jpedsurg.2022.01.039
- Esposito C, Corcione F, Settimi A, et al. Twenty-five year experience with laparoscopic cholecystectomy in the pediatric population-from 10 mm clips to indocyanine green fluorescence technology: long-term results and technical considerations. J Laparoendosc Adv Surg Tech A. 2019;29(9):1185–1191. doi: 10.1089/lap.2019.0254
- Onishi S, Yamada K, Murakami M, et al. Co-injection of bile and indocyanine green for detecting pancreaticobiliary maljunction of choledochal cyst. Eur J Pediatr Surg Rep. 2022;10(1):e127–e130. doi: 10.1055/s-0042-1747913
- Ko JW, Choi SH, Kwon SW, Ko KH. Robot-assisted hepatectomy and complete excision of the extrahepatic bile duct for type IV-A choledochal cysts. Surg Endosc. 2016;30(12):5626–5627. doi: 10.1007/s00464-016-4923-9
- Santore MT, Deans KJ, Behar BJ, et al. Laparoscopic hepaticoduodenostomy versus open hepaticoduodenostomy for reconstruction after resection of choledochal cyst. J Laparoendosc Adv Surg Tech A. 2011;21(4):375–378. doi: 10.1089/lap.2010.0478
- Moslim MA, Takahashi H, Seifarth FG, et al. Choledochal cyst disease in a Western Center: A 30-year experience. J Gastrointest Surg. 2016;20(8):1453–1463. doi: 10.1007/s11605-016-3181-4
- Ohi R, Yaoita S, Kamiyama T, et al. Surgical treatment of congenital dilatation of the bile duct with special reference to late complications after total excisional operation. J Pediatr Surg. 1990;25(6):613–617. doi: 10.1016/0022-3468(90)90346-b
- Farello GA, Cerofolini A, Rebonato M, et al. Congenital choledochal cyst: video-guided laparoscopic treatment. Surg Laparosc Endosc. 1995;5(5):354–358.
- Razumovsky AYu, Degtyareva AV, Kulikova NV, et al. Laparoscopic surgery for biliary tract malformations in children. Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care. 2012;2(1):19–24. EDN: OZPIMF
- Razumovski AYu, Degtyareva AV, Uskova NG, et al. Endosurgical treatment of chole ductus lesions in children. Experimental and Clinical Gastroenterology Journal. 2014;(1):59–65. EDN: SFCGVR
- Meehan JJ, Elliott S, Sandler A. The robotic approach to complex hepatobiliary anomalies in children: preliminary report. J Pediatr Surg. 2007;42(12):2110–2114. doi: 10.1016/j.jpedsurg.2007.08.040
- Tan HL, Shankar KR, Ford WD. Laparoscopic resection of type I choledochal cyst. Surg Endosc. 2003;17(9):1495. doi: 10.1007/s00464-003-4502-8
- Liem NT, Pham HD, Vu HM. Is the laparoscopic operation as safe as open operation for choledochal cyst in children? J Laparoendosc Adv Surg Tech A. 2011;21(4):367–370. doi: 10.1089/lap.2010.0375
- Liem NT, Pham HD, Dung LA, et al. Early and intermediate outcomes of laparoscopic surgery for choledochal cysts with 400 patients. J Laparoendosc Adv Surg Tech A. 2012;22(6):599–603. doi: 10.1089/lap.2012.0018
- Kim JH, Choi TY, Han JH, et al. Risk factors of postoperative anastomotic stricture after excision of choledochal cysts with hepaticojejunostomy. J Gastrointest Surg. 2008;12(5):822–828. doi: 10.1007/s11605-007-0415-5
- Yeung F, Chung PHY, Wong KK, Tam PK. Biliary-enteric reconstruction with hepaticoduodenostomy following laparoscopic excision of choledochal cyst is associated with better postoperative outcomes: a single-centre experience. Pediatr Surg Int. 2015;31(2):149–153. doi: 10.1007/s00383-014-3648-x
- Ieiri S, Murakami M, Baba T, et al. Technical tips concerning laparoscopic hepaticojejunostomy for choledochal cyst in children with a focus on secure anastomosis for small hepatic ducts. Ann Laparosc Endosc Surg. 2019;4:20. doi: 10.21037/ales.2019.02.03
- Esposito C, Alberti D, Settimi A, et al. Indocyanine green (ICG) fluorescent cholangiography during laparoscopic cholecystectomy using RUBINA™ technology: preliminary experience in two pediatric surgery centers. Surg Endosc. 2021;35(11):6366–6373. doi: 10.1007/s00464-021-08596-7
- Calabro KA, Harmon CM, Vali K. Fluorescent cholangiography in laparoscopic cholecystectomy and the use in pediatric patients. J Laparoendosc Adv Surg Tech A. 2020;30(5):586–589. doi: 10.1089/lap.2019.0204
- Hirayama Y, Iinuma Y, Yokoyama N, et al. Near-infrared fluorescence cholangiography with indocyanine green for biliary atresia. Real-time imaging during the Kasai procedure: a pilot study. Pediatr Surg Int. 2015;31(12):1177–1182. doi: 10.1007/s00383-015-3799-4
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